| Project/Area Number |
21580387
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
|
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
NISHIFUJI Koji 東京農工大学, 大学院・農学研究院, 准教授 (20365422)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Toshiroh 東京農工大学, 大学院・農学研究院, 教授 (50262754)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SUGAI Motoyuki 広島大学, 医歯(薬)学総合研究科, 教授 (10201568)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 感染症 / ブドウ球菌 / 表皮剥脱毒素 / デスモグレイン / 皮膚 / 膿痂疹 / ブドウ球菌性熱傷様皮膚症候群 / ブタ滲出性表皮炎 / 細胞接着 / 滲出性表皮炎 |
|---|
| Research Abstract |
In this project, we revealed that amino acid motifs critical for substrate specificity of Staphylococcus aureus exfoliative toxin B(ETB) may be located between amino acid residues of 65-232. This project also revealed that two S. pseudintermedius ETs selectively digest canine desmoglein 1, a cell-cell adhesion molecule in canine epidermis.
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