| Project/Area Number |
21580392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Ken 山口大学, 農学部, 教授 (90284273)
KATO Hirotomo 山口大学, 農学部, 准教授 (00346579)
|
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 急性期蛋白 / α1酸性糖蛋白 / 糖鎖修飾 / 腫瘍 / ウイルス / 急性期糖蛋白 / モノクローナル抗体 |
|---|
| Research Abstract |
For the purpose of analyses on dynamism of glycan chain response in acute phase proteins under severe disease conditions, alpha-1 acid glycoprotein(AGP) in bovine, and feline were purified from sera and ascites, respectively, and recombinant AGP. were also purified. These proteins were used for the preparation of monoclonal antibodies(Mabs) for the analyses of AGPs. In results, several Mabs for each animal were obtained and analysed for the epitopes of each AGP, which were useful for quantification of AGPs and analyses of glycan chain.
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