Research on the pathophysiology of resistance to glucocorticoid feedback in canine pituitary ACTH-secreting adenomas.
| Project/Area Number |
21580394
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
HARA Yasushi 日本獣医生命科学大学, 獣医学部, 教授 (00228628)
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| Co-Investigator(Renkei-kenkyūsha) |
TAGAWA Masahiro 日本獣医生命科学大学, 獣医学部, 教授 (90097072)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 犬下垂体ACTH産生腺腫 / クッシング病 / コルチゾール抵抗性 / ステロイド代謝酵素 / 副腎皮質機能亢進症 / 下垂体 / コルチゾール / グルココルチコイド受容体 / ACTH産生腺腫 |
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| Research Abstract |
Our study revealed that the expression of cortisol-metabolizing enzyme in the pituitary ACTH-secreting adenomas was higher than canine normal ACTH-secreting cells. Moreover, the expression of glucocorticoid receptor was seemed to be decreased in the pituitary ACTH-secreting adenomas. These changes may explain, in part, the resistance to glucocorticoid feedback in canine pituitary ACTH-secreting adenomas.
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Report
(4 results)
Research Products
(14 results)
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[Presentation] 下垂体切除術2011
Author(s)
原康
Organizer
獣医麻酔外科学会
Place of Presentation
大宮ソニックシティ
Year and Date
2011-06-11
Related Report
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