Analysis of aberrantly activated receptor tyrosine kinase and development of molecular targeting therapy in small animals with malignancies.
| Project/Area Number |
21580395
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
MAKOTO Bonkobara 日本獣医生命科学大学, 獣医学部, 准教授 (50343611)
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| Co-Investigator(Renkei-kenkyūsha) |
TOSHIRO Arai 日本獣医生命科学大学, 獣医学部, 教授 (70184257)
ONO Kenichiro 日本獣医生命科学大学, 獣医学部, 客員教授 (50111480)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | c-kit / 猫 / 肥満細胞腫 / チロシンキナーゼ / 分子標的療法 / 犬 / 悪性黒色腫 / 分子標的薬 / NFkB / プロテアソーム阻害剤 / c-kit変異 / イマチニブ |
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| Research Abstract |
The mutation status of KIT and effects of imatinib on the mutant KIT were investigated in vitro and in clinical cases of cats and dogs with mast cell tumors(MCTs). Mutations in c-kit exon 8 and 9 were identified in tumor cells from cats and dogs with MCTs. These mutations caused constitutive phosphorylation of KIT. Imatinib suppressed the phosphorylation of the mutant KIT. A beneficial response to imatinib was observed in cats and dogs that had a mutation in c-kit exon 8 or 9.MCTs with mutations in c-kit exon 8 and 9 are potentially sensitive to imatinib in dogs and cats.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Establishment of a PCR analysis method for canine BRCA22012
Author(s)
Yoshikawa Y, Morimatsu M, Ochiai K, Okuda K, Taoda T, Chikazawa S, Shimamura A, Omi T, Bonkobara M, Orino K, Watanabe K.
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Journal Title
BMC Res Notes
Volume: (in press)
Issue: 1
Pages: 173-173
DOI
Related Report
Peer Reviewed
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[Journal Article] Establishment and Characterization of Canine Rhabdomyosarcoma Cell Line, CMS-C2011
Author(s)
Azakami D, Shibutani H, Dohi M, Takasaki M, Ishioka K, Mori A, Momota Y, Bonkobara M, Washizu T, Michishita M, Hatakeyama H, Ogasawara S, Sako T.
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Journal Title
Journal of Veterinary Medical Science
Volume: 73(8)
Pages: 1105-1108
NAID
Related Report
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[Journal Article] Imatinib elicited a favorable response in a dog with a mast cell tumor carrying a c-kit c. 1523A> T mutation via suppression of constitutive KIT activation2011
Author(s)
Yamada O, Kobayashi M, Sugisaki O, Ishii N, Ito K, Kuroki S, Sasaki Y, Isotani M, Ono K, Washizu T, Bonkobara M.
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Journal Title
Veterinary Immunology and Immunopathology
Volume: 142
Pages: 101-106
Related Report
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[Journal Article] Imatinib elicited a favorable response in a dog with a mast cell tumor carrying a c-kit c.1523A>T mutation via suppression of constitutive KIT activation2011
Author(s)
Yamada O, Kobayashi M, Sugisaki O, Ishii N, Ito K, Kuroki S, Sasaki Y, Isotani M, Ono K, Washizu T, Bonkobara M
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Journal Title
Veterinary Immunology and Immunopathology
Volume: 142
Pages: 101-106
Related Report
Peer Reviewed
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