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Effects of the halogenated derivatives of polycyclic aromatic hydrocarbons on gene expression

Research Project

Project/Area Number 21580408
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Boundary agriculture
Research InstitutionTokoha Gakuen University

Principal Investigator

KURUTO Ryoko  常葉学園大学, 教育学部, 准教授 (50205217)

Co-Investigator(Kenkyū-buntansha) OHURA Takeshi  名城大学, 農学部, 准教授 (60315851)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords環境汚染 / ハロゲン化 / 多環芳香族炭化水素 / 遺伝子発現 / PCRアレイ
Research Abstract

Polycyclic aromatic hydrocarbons(PAHs) are ubiquitous environmental contaminants that are formed by the incomplete combustion of organic compounds. Recently, chlorinated and brominated PAHs were detected in the environmental samples. Then their effects on gene expression were investigated by real-time PCR analysis in human breast carcinoma MCF7 and MDA-MB-231 cells. PCR arrays revealed that the expression levels of several genes in halogenated PAHs were different from that in parent compounds. In addition, the different results were obtained between both cell lines.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (64 results)

All 2012 2011 2010 2009

All Journal Article (27 results) (of which Peer Reviewed: 23 results) Presentation (31 results) Book (6 results)

  • [Journal Article] Evaluation of chlorinated benz [a] anthracene on hepatic toxicity in rats and mutagenic activity in Salmonella typhimurium2011

    • Author(s)
      T. Kido, 他10名
    • Journal Title

      Environ. Toxicol.

      Volume: (in press) Issue: 1 Pages: 21-30

    • DOI

      10.1002/tox.20693

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Environmental analysis of chlorinated and brominated polycyclic aromatic hydro-carbons by comprehensive two-dimensional gas chromatography coupled to high-resolution time-of-flight mass spectrometry2011

    • Author(s)
      T. Ieda, 他4名
    • Journal Title

      J. Chromatogr. A

      Volume: 1218 Issue: 21 Pages: 3224-3232

    • DOI

      10.1016/j.chroma.2011.01.013

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of polycyclic aromatic hydrocarbon pollution in Chinese and Japanese residential air2011

    • Author(s)
      H.Lu
    • Journal Title

      J.Environ.Sci.

      Volume: 23 Pages: 1512-1517

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive Two-Dimensional Gas Chromatography Coupled to High-Resolution Time-Of-Flight Mass Spectrometry for Analysis of Cl-/Br-PAHs in Environmental Samples2011

    • Author(s)
      T.Ieda
    • Journal Title

      Organohalogen Compd

      Volume: 73 Pages: 2155-2158

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of Halogenated Polycyclic Aromatic Hydrocarbons in Flue Gas from Waste Incinerators2011

    • Author(s)
      Y.Horii
    • Journal Title

      Organohalogen Compd

      Volume: 73 Pages: 108-111

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential action of chlorinated polycyclic aromatic hydrocarbons on aryl hydrocarbon receptor-mediated signaling in breast cancer cells2010

    • Author(s)
      T. Ohura, M. Morita, R. Kuruto-Niwa, 他3名
    • Journal Title

      Environ. Toxicol.

      Volume: 25 Issue: 2 Pages: 180-187

    • DOI

      10.1002/tox.20488

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the chlorinated derivatives of environmental pollutant on gene expression2010

    • Author(s)
      R. Kuruto, T. Ohura, Y. Terao
    • Journal Title

      Tokoha Gakuen University Research Review(Faculty of Education)

      Volume: 30 Pages: 377-391

    • NAID

      40018708155

    • Related Report
      2011 Final Research Report
  • [Journal Article] Inhibitory effects of chrysoeriol on DNA adduct formation with benzo [a] pyrene in MCF-7 breast cancer cells2010

    • Author(s)
      H. Takemura, 他7名
    • Journal Title

      Toxicology

      Volume: 274 Issue: 1-3 Pages: 42-48

    • DOI

      10.1016/j.tox.2010.05.009

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aryl hydrocarbon receptor activities of hydroxylated polycyclic aromatic hydro-carbons in recombinant yeast cells2010

    • Author(s)
      T. Ohura, R. Kurihara, S. Hashimoto
    • Journal Title

      Toxicol. Environ. Chem.

      Volume: 92 Pages: 737-742

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the chlorinated derivatives of environmental pollutant on gene expression2010

    • Author(s)
      R.Kuruto
    • Journal Title

      Tokoha Gakuen University Research Review (Faculty of Education)

      Volume: 30 Pages: 377-391

    • NAID

      40018708155

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Inhibitory effects of chrysoeriol on DNA adduct formation with benzo[a] pyrene in MCF-7 breast cancer cells.2010

    • Author(s)
      Takemura, H.
    • Journal Title

      Toxicology

      Volume: 274 Pages: 42-48

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A simple method for screening emission sources of carbonyl compounds in indoor air.2010

    • Author(s)
      Yamashita, S.
    • Journal Title

      J.Hazard.Mater.

      Volume: 178 Pages: 370-376

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Benzo[a]pyrene exposed to solar-simulated light inhibits apoptosis and augments carcinogenicity.2010

    • Author(s)
      Teranishi, M.
    • Journal Title

      Chem.Biol.Interact.

      Volume: 185 Pages: 4-11

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aryl hydrocarbon receptor activities of hydroxylated polycyclic aromatic hydrocarbons in recombinant yeast cells.2010

    • Author(s)
      Ohura, T.
    • Journal Title

      Toxicol.Environ.Chem.

      Volume: 92 Pages: 737-742

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential action of chlorinated polycyclic aromatic hydrocarbons on aryl hydrocarbon receptor-mediated signaling in breast cancer cells.2010

    • Author(s)
      Ohura, T.
    • Journal Title

      Environ Toxicol.

      Volume: 25 Pages: 180-187

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells.2010

    • Author(s)
      Takemura, H.
    • Journal Title

      J.Steroid Biochem.Mol.Biol.

      Volume: 118 Pages: 70-76

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential action of chlorinated polycyclic aromatic hydrocarbons on aryl hydrocarbon receptor-mediated signaling in breast cancer cells2010

    • Author(s)
      Ohura, T.
    • Journal Title

      Environ Toxicol. 25

      Pages: 180-187

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells2010

    • Author(s)
      Takemura, H.
    • Journal Title

      J.Steroid Biochem.Mol.Biol. 118

      Pages: 70-76

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the chlorinated derivatives of environmental pollutant on gene expression2010

    • Author(s)
      Kuruto, R.
    • Journal Title

      Tokoha Gakuen University Research Review 30

      Pages: 377-391

    • NAID

      40018708155

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Aryl hydrocarbon receptor-mediated gene expression by chlorinated polycyclic aromatic hydrocarbons and cross-talk with estrogen receptors2009

    • Author(s)
      H. Sakakibara, T. Ohura, 他5名
    • Journal Title

      Interdiscip. Stud. Environ. Chem.

      Volume: 2 Pages: 197-202

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of novel halogenated polycyclic aromatic hydrocarbons in urban particulate matters : Occurrence, photostability, and AhR activity2009

    • Author(s)
      T. Ohura, 他3名
    • Journal Title

      Environ. Sci. Technol

      Volume: 43 Pages: 2269-2275

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relative potencies of individual chlorinated and brominated polycyclic aromatic hydro-carbons for induction of aryl hydrocarbon receptor-mediated responses2009

    • Author(s)
      Y. Horii, 他5名
    • Journal Title

      Environ. Sci. Technol

      Volume: 43 Pages: 2159-2165

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aryl Hydrocarbon Receptor-mediated Gene Expression by Chlorinated Polycyclic Aromatic Hydrocarbons and Cross-talk with Estrogen Receptor2009

    • Author(s)
      Sakakibara, H.
    • Journal Title

      Interdiscip.Stud.Environ.Chem. 2

      Pages: 197-202

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Chlorinated polycyclic aromatic hydrocarbons in sediments from industrial areas in Japan and the United States2009

    • Author(s)
      Horii, Y.
    • Journal Title

      Arch.Environ.Contam.Toxicol. 57

      Pages: 651-660

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of novel halogenated polycyclic aromatic hydrocarbons in urban particulate matters : Occurrence, photostability, and AhR activity2009

    • Author(s)
      Ohura, T.
    • Journal Title

      Environ.Sci.Technol. 43

      Pages: 2269-2275

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relative potencies of individual chlorinated and brominated polycyclic aromatic hydrocarbons for induction of aryl hydrocarbon receptor-mediated responses2009

    • Author(s)
      Horii, Y.
    • Journal Title

      Environ.Sci.Technol. 43

      Pages: 2159-2165

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chlorinated and parent polycyclic aromatic hydrocarbons in environmental samples from an electronic waste recycling facility and a chemical industrial complex in China2009

    • Author(s)
      Ma, J.
    • Journal Title

      Environ.Sci.Technol. 43

      Pages: 643-649

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ハロゲン化PAHsの大気環境動態と生体影響評価2012

    • Author(s)
      大浦健
    • Organizer
      地環研共同研究課題「大気の遺伝毒性及び環境ホルモン活性と酸化的二次生成物質に関する地域特性の調査研究」共同研究ミーティング
    • Place of Presentation
      国立環境研究所(招待講演)
    • Year and Date
      2012-01-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 紫外線照射下における塩素化多環芳香族類の動態解析2012

    • Author(s)
      三輪良
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      神奈川
    • Related Report
      2011 Annual Research Report
  • [Presentation] GC/QMSによる塩素化多環芳香族炭化水素類の高感度分析法の開発及び環境分析への適用2012

    • Author(s)
      神谷優太
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      神奈川
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大気汚染は改善したのか?-大気汚染物質と暴露リスク2011

    • Author(s)
      大浦健
    • Organizer
      平成23年度農学部公開講座、身近なバイオサイエンス~身近に潜む化学物質汚染~
    • Place of Presentation
      愛知(招待講演)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] ハロゲン化多環芳香族類の環境・生体内動態解析2011

    • Author(s)
      大浦健
    • Organizer
      埼玉県環境科学国際センター職員研修
    • Place of Presentation
      加須(招待講演)
    • Year and Date
      2011-08-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多環芳香族炭化水素及びそのハロゲン置換体の乳がん細胞に及ぼす影響2011

    • Author(s)
      久留戸涼子
    • Organizer
      第14回日本内分泌攪乱化学物質学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Diurnal variation of chlorinated polycyclic aromatic hydrocarbons in urban air, Japan2011

    • Author(s)
      T. Ohura
    • Organizer
      The 23rd International Symposium on Polycyclic Aromatic Compounds
    • Place of Presentation
      Munster, Germany
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 都市大気における塩素化多環芳香族炭化水素類の日内変動2011

    • Author(s)
      大浦健
    • Organizer
      第20回環境化学討論会
    • Place of Presentation
      熊本
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 塩素化多環芳香族類の光分解挙動と遺伝毒性に関する研究2011

    • Author(s)
      三輪良
    • Organizer
      第20回環境化学討論会
    • Place of Presentation
      熊本
    • Related Report
      2011 Final Research Report
  • [Presentation] Halogenated Polycyclic Aromatic Hydrocarbons in Urban Air from Albany, USA2011

    • Author(s)
      Y.Horii
    • Organizer
      SETAC North America, 32nd Annual Meeting
    • Place of Presentation
      Boston, MA
    • Related Report
      2011 Annual Research Report
  • [Presentation] A methoxyflavonoid, chrysoeriol, is responsible for inhibition of DNA adduct formation by benzo[a]pyrene in MCF-7 breast cancer cells2011

    • Author(s)
      H.Takemura
    • Organizer
      5th International Conference on Polyphenols and Health
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多環芳香族炭化水素及びその臭素置換体の遺伝子発現に及ぼす影響2010

    • Author(s)
      久留戸涼子
    • Organizer
      第13回日本内分泌攪乱化学物質学会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 多環芳香族炭化水素及びその臭素置換体の遺伝子発現に及ぼす影響2010

    • Author(s)
      久留戸涼子
    • Organizer
      第13回日本内分泌攪乱化学物質学会
    • Place of Presentation
      東京大学山上会館(東京)
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of 7-chlorinated benz[a]anthracene on hepatic CYP1 family expression in rats, and mutagenic activity in Salmonella typhimurium.2010

    • Author(s)
      Kido, T.
    • Organizer
      2nd Asian Conference on Environmental Mutagens
    • Place of Presentation
      Pattaya (Thailand)
    • Year and Date
      2010-12-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] GCxGC-負イオン化学イオン化-高分解能TOF-MSを用いた環境試料中有機ハロゲン化合物の分析2010

    • Author(s)
      家田曜世
    • Organizer
      日本分析化学会 第59年会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chrysoeriol prevents formation of a carcinogenic estrogen metabolite, 4-hydroxy estradiol, through the selective inhibition of CYP1B1.2010

    • Author(s)
      Takemura, H.
    • Organizer
      6th International Symposium on Hormonal Oncogenesis
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル(浦安)
    • Year and Date
      2010-09-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 焼却排ガス中塩素化・臭素化多環芳香族炭化水素の分布2010

    • Author(s)
      堀井勇一
    • Organizer
      第19回環境化学討論会
    • Place of Presentation
      春日井
    • Year and Date
      2010-06-21
    • Related Report
      2011 Final Research Report
  • [Presentation] GCxGC-高分解能TOF-MSによる環境試料中の塩素化・臭素化PAHs及びその他有機ハロゲン化合物の網羅的分析2010

    • Author(s)
      家田曜世
    • Organizer
      第19回環境化学討論会
    • Place of Presentation
      中部大学(春日井)
    • Year and Date
      2010-06-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラットにおける7-クロロベンゾ[a]アントラセンの生体蓄積性の評価2010

    • Author(s)
      小島光博
    • Organizer
      第19回環境化学討論会
    • Place of Presentation
      中部大学(春日井)
    • Year and Date
      2010-06-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] シトクロムP450 1A2が誘発する7-クロロベンゾ[a]アントラセンの変異原性2010

    • Author(s)
      貴戸武利
    • Organizer
      第19回環境化学討論会
    • Place of Presentation
      中部大学(春日井)
    • Year and Date
      2010-06-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 焼却排ガス中塩素化・臭素化多環芳香族炭化水素の分布2010

    • Author(s)
      堀井勇一
    • Organizer
      第19回環境化学討論会
    • Place of Presentation
      中部大学(春日井)
    • Year and Date
      2010-06-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of Cl-/Br-PAHs and other organohalogen compounds in environmental samples by GC x GC - high resolution TOF-MS.2010

    • Author(s)
      Ieda, T.
    • Organizer
      7th GC x GC symposium
    • Place of Presentation
      Riva del Garda (Italy)
    • Year and Date
      2010-06-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of 7-chlorinated benz [a] anthracene on hepatic CYP1 family expression in rats, and mutagenic activity in Salmonella typhimurium2010

    • Author(s)
      T. Kido
    • Organizer
      2^<nd> Asian Conference on Environmental Mutagens
    • Place of Presentation
      Pattaya, Thailand
    • Related Report
      2011 Final Research Report
  • [Presentation] 7-クロロベンゾ[a]アントラセンのラット肝におけるCYP1A2誘導と変異原性2010

    • Author(s)
      貴戸武利
    • Organizer
      変異機構研究会第23回夏の学校
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] 多環芳香族炭化水素及びその臭素置換体のAhR、ER標的遺伝子の発現への影響2009

    • Author(s)
      久留戸涼子
    • Organizer
      第12回日本内分泌攪乱化学物質学会
    • Place of Presentation
      東京大学山上会館(東京)
    • Year and Date
      2009-12-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] GCxGC-高分解能TOF-MSによる環境試料中塩素化・臭素化PAHsの分析2009

    • Author(s)
      家田曜世
    • Organizer
      日本分析化学会第58年会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] GCxGC-高分解能TOF-MSによる環境試料中塩素化・臭素化PAHsの分析2009

    • Author(s)
      家田曜世
    • Organizer
      日本分析化学会 第58年会
    • Place of Presentation
      北海道大学高等教育機能開発総合センター(札幌)
    • Year and Date
      2009-09-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 塩素化多環芳香族炭化水素の土壌汚染と発生源に関する研究2009

    • Author(s)
      大浦健
    • Organizer
      第18回環境化学討論会
    • Place of Presentation
      つくば
    • Year and Date
      2009-06-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 食塩電解過程に由来するダイオキシン類及び類縁化合物2009

    • Author(s)
      山本央
    • Organizer
      第18回環境化学討論会
    • Place of Presentation
      つくば国際会議場(つくば)
    • Year and Date
      2009-06-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 塩素化多環芳香族炭化水素の土壌汚染と発生源に関する研究2009

    • Author(s)
      大浦健
    • Organizer
      第18回環境化学討論会
    • Place of Presentation
      つくば国際会議場(つくば)
    • Year and Date
      2009-06-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多環芳香族炭化水素及びその臭素置換体のAhR、ER標的遺伝子の発現への影響2009

    • Author(s)
      久留戸涼子
    • Organizer
      第12回日本内分泌攪乱化学物質学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Book] Polycyclic Aromatic Hydrocarbonson : Pollution, Health Effects and Chemistry2009

    • Author(s)
      T. Ohura
    • Publisher
      NOVA Science Publishers
    • Related Report
      2011 Final Research Report
  • [Book] Environment and Regional Air Pollution2009

    • Author(s)
      T. Ohura
    • Publisher
      NOVA Science Publishers
    • Related Report
      2011 Final Research Report
  • [Book] Airborne Particulates2009

    • Author(s)
      T. Ohura
    • Publisher
      NOVA Science Publishers
    • Related Report
      2011 Final Research Report
  • [Book] Environment and Regional Air Pollution(D.Gallo, R.Mancini, Eds.)2009

    • Author(s)
      Ohura, T.
    • Total Pages
      496
    • Publisher
      NOVA Science Publishers, NY
    • Related Report
      2009 Annual Research Report
  • [Book] Airborne Particulates(M.Cheng, W.Liu, Eds.)2009

    • Author(s)
      Ohura, T.
    • Total Pages
      343
    • Publisher
      NOVA Science Publishers, NY
    • Related Report
      2009 Annual Research Report
  • [Book] Polycyclic Aromatic Hydrocarbons : Pollution, Health Effects and Chemistry(Pierre A.Haines, Milton D.Hendrickson, Eds.)2009

    • Author(s)
      Ohura, T., Sakakibara, H.
    • Total Pages
      361
    • Publisher
      NOVA Science Publishers, NY
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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