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Studies on a novel protein promoting cell self-renewal and translation for the application of muscle anti-aging

Research Project

Project/Area Number 21580412
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied molecular and cellular biology
Research InstitutionNagoya University

Principal Investigator

NADANO Daita  名古屋大学, 生命農学研究科, 准教授 (00228074)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords細胞増殖 / 分化 / 発現制御 / 翻訳 / 細胞・組織 / シグナル伝達 / 発生・分化 / 老化
Research Abstract

The human protein, named bystin, has been indicated to benecessary for self-renewal of undifferentiated cells such as stem cells and to be important for translational activation in cells, and thus has a unique property playing two distinct roles. Because the molecular mechanisms for these roles were unclear, proteinscooperating with bystin were surveyed, and novel factors were identified and analyzed. These findings are expected to lead to useful mechanisms applicable to differentiation of muscular cells, which requires cell number increase and growth.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (7 results)

  • [Journal Article] The murine Gcap14gene encodes a novel microtubule binding and bundling protein.2012

    • Author(s)
      Hosono, H., Yamaguchi, N., Oshima, K., Matsuda, T., and Nadano, D.
    • Journal Title

      FEBS Lett

      Volume: 586(10) Issue: 10 Pages: 1426-1430

    • DOI

      10.1016/j.febslet.2012.04.008

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin.2011

    • Author(s)
      Moriya, H., Uchida, K., Okajima, T., Matsuda, T., and Nadano, D.
    • Journal Title

      Arch. Biochem. Biophys

      Volume: 508(1) Issue: 1 Pages: 87-92

    • DOI

      10.1016/j.abb.2011.01.015

    • NAID

      120004384226

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin2011

    • Author(s)
      Moriya, H.(第一著者)
    • Journal Title

      Arch.Biochem.Biophys.

      Volume: 508 Pages: 87-92

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA-binding protein in early involution of the mouse mammary gland2010

    • Author(s)
      Taga, Y., Miyoshi, M., Okajima, T., Matsuda, T., and Nadano, D.
    • Journal Title

      Cell Biochem. Function

      Volume: 28(4) Issue: 4 Pages: 321-328

    • DOI

      10.1002/cbf.1662

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of rodent ribosomes revealed heterogeneity including ribosomal proteins L10-like, L22-like 1, andL39-like2010

    • Author(s)
      Sugihara, Y., Honda, H., Iida, T., Morinaga, T., Hino, S., Okajima, T., Matsuda, T., and Nadano, D.
    • Journal Title

      J. Proteome Res

      Volume: 9(3) Issue: 3 Pages: 1351-1366

    • DOI

      10.1021/pr9008964

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA-binding protein in early involution of the mouse mammary gland.2010

    • Author(s)
      Taga, Y(第一著者)
    • Journal Title

      Cell Biochem. Function

      Volume: 280 Pages: 321-328

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of rodent ribosomes revealed heterogeneity including ribosomal proteins L10-like, L22-like 1, and L39-like.2010

    • Author(s)
      Sugihara, Y.(第一著者)
    • Journal Title

      J. Proteome Res. VOL. 9

      Pages: 1351-1366

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 発達段階に依存した精巣特異的リボソームタンパク質L10-likeの発現2012

    • Author(s)
      佐土原英司・杉原圭彦・大島健司・松田幹・灘野大太
    • Organizer
      2012年度日本農芸化学会全国大会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2012-03-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 発達段階に依存した精巣特異的リボソームタンパク質L10-likeの発現2012

    • Author(s)
      佐土原英司(代表者)
    • Organizer
      2012年度日本農芸化学会全国大会
    • Place of Presentation
      京都女子大学(京都府)
    • Year and Date
      2012-03-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 精巣特異的リボソームタンパク質の発達段階に依存した発現2012

    • Author(s)
      佐土原英司・杉原圭彦・大島健司・松田幹・灘野大太
    • Organizer
      第1回リボソームミーティング
    • Place of Presentation
      広島大学
    • Year and Date
      2012-03-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 精巣特異的リボソームタンパク質の発達段階に依存した発現2012

    • Author(s)
      灘野大太(代表者)
    • Organizer
      第1回リボソームミーティング
    • Place of Presentation
      広島大学(広島県)
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロテオミクスによる哺乳類リボソームにおける不均一性の解析2010

    • Author(s)
      灘野大太・杉原圭彦・本多弘樹・日野真吾・岡島徹也・松田幹
    • Organizer
      2010年度日本農芸化学会全国大会
    • Place of Presentation
      東京大学
    • Year and Date
      2010-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] プロテオミクスによる哺乳類リボソームにおける不均一性の解析2010

    • Author(s)
      灘野大太(発表代表名)
    • Organizer
      2010年度日本農芸化学会全国大会シンポジウム「リボソーム生合成研究の新展開」
    • Place of Presentation
      東京大学駒場キャンパス(東京都)
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Proteomic analysis of rodent ribosomes revealedheterogeneity including ribosomalproteins2009

    • Author(s)
      Sugihara, Y., Honda, H., Okajima, T., Matsuda, T., and Nadano, D.
    • Organizer
      The 8th international conference onribosome biogenesis
    • Place of Presentation
      Regensburg, Germany
    • Year and Date
      2009-08-28
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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