Applications and development of highly active nickel catalyst for hydrogenation reaction
| Project/Area Number |
21590002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 触媒的不斉反応 / 不斉水素化 / 触媒 / フェロセン / ニッケル / 動的速度論分割 / 不斉水素化反応 |
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| Research Abstract |
Asymmetric hydrogenation reactions of.-amino aromatic ketone using the nickel catalyst prepared from nickel acetate tetrahydrate, the chiral bidentate phosphine ligand, and NaBArF were examined. It was found that highly anti-and enantioselective selective asymmetric hydrogenation through dynamic kinetic resolution(DKR) proceeded in the presence of sodium acetate(1 equiv) as a base and in toluene under hydrogen pressure(100 atm).
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] Sequential one-pot glycosylation with glycosyl N-trichloroacety lcarbamate and trichloroacetate including dehydrative approach using 1-hydroxy sugars2011
Author(s)
Shirahata, T.; Kojima, Teruya, S.; Matsuo, J.; Yokoyama, M.; Unagiike, S.; Sunazuka, T.; Makino, K.; Kaji, E.; Omura, S.; Kobayashi, Y
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Journal Title
Tetrahedron
Volume: 67
Issue: 35
Pages: 6842-6896
DOI
Related Report
Peer Reviewed
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