| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Asymmetric hydrogenation reactions of.-amino aromatic ketone using the nickel catalyst prepared from nickel acetate tetrahydrate, the chiral bidentate phosphine ligand, and NaBArF were examined. It was found that highly anti-and enantioselective selective asymmetric hydrogenation through dynamic kinetic resolution(DKR) proceeded in the presence of sodium acetate(1 equiv) as a base and in toluene under hydrogen pressure(100 atm).
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