| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
Synthetic and medicinal studies of 2, 3-benzodiazepine derivatives were performed for the purpose of exploring novel drug seeds of neuronal disorders. We could establish new method of constructing 2, 3-benzodiazepine nucleus based on our original tandem electrocyclic reactions using benzocyclobutenes and diazomethylene anion as starting materials, and succeed in constructing a novel diazabenzotropone compounds library. Although these compounds were found not to exhibit neuronal protecting activity, some of them showed notable apoptosis-inducing activity against some lymphoma cells. Thus, we found that novel diazabenzotropone derivatives, synthesized utilizing our original reactions, could be a new candidate of novel anticancer agents.
|
