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Development of new radical chemistry-based strategies for the construction of densely functionalized organic molecules

Research Project

Project/Area Number 21590009
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionOsaka University

Principal Investigator

YOSHIMITSU Takehiko  大阪大学, 大学院・薬学研究科, 准教授 (30301576)

Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords全合成 / ラジカル / 生物活性天然物 / 炭素-水素(C-H)結合変換 / 創薬 / ラジカル反応 / C-H 変換 / アルカロイド / 抗生物質 / 合成戦略 / C-H変換
Research Abstract

Bioactive natural products often possess unique chemical structures with dense functionalities, serving as a useful medicinal resource. The authors have been engaged in synthetic radical chemistry that would revolutionize strategies for providing access to this class of attractive molecules. In the present study, we succeeded in devising new radical reactions associated with sp3carbon-hydrogen (sp3C-H) transformation (photochemical sp3C-H carbamoylation of tertiary amines) and iron(II)-catalyzed aminohalogenation reactions of N-tosyloxycarbamates, and accomplished radical chemistry-based total syntheses of bioactive natural products including kainic acid, platencin, and agelastatin A. Furthermore, we developed a novel means for asymmetric synthesis, which employsremote stereoinduction that allows facile construction of carbocyclic building blocks bearing quaternary stereocenters. The biological evaluation of platencin prepared by the above-mentioned total synthesishas allowed the authors to assess its significant inhibitory activity against multi-drug-resistant Mycobacterium tuberculosis, adding a new dimension to the development of antitubercular agents.

Report

(4 results)
  • 2012 Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (96 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (26 results) (of which Peer Reviewed: 14 results) Presentation (66 results) (of which Invited: 2 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Formal synthesis of (-)-agelastatin A: an iron(II)-mediated cyclization strategy2013

    • Author(s)
      Shigeoka, D.; Kamon, T.; Yoshimitsu, T.
    • Journal Title

      Beilstein J. Org. Chem

      Volume: 9 Pages: 860-865

    • Related Report
      2012 Final Research Report
  • [Journal Article] Potent growth inhibitory activity of (±)-platencin towards multi-drug-resistant and extensively drug-resistant2013

    • Author(s)
      Moustafa, G. A. I.; Nojima, S.; Yamano, Y.; Aono, A.; Arai, M.; Mitarai, S.; Tanaka, T.; Yoshimitsu, T.
    • Journal Title

      Mycobacterium tuberculosis, Med. Chem. Commun.

      Volume: 4 Pages: 720-723

    • Related Report
      2012 Final Research Report
  • [Journal Article] Stereoconvergent route to chiral cyclohexenone building blocks: formal synthesis of (-)-dysidiolide2012

    • Author(s)
      Moustafa, G. A. I.; Kamada, Y.; Tanaka, T.; Yoshimitsu, T.
    • Journal Title

      Org. Biomol. Chem

      Volume: 10 Pages: 8609-8615

    • Related Report
      2012 Final Research Report
  • [Journal Article] Iron(II)-catalyzed intramolecular aminobromination of allyl N-tosyloxycarbamates2012

    • Author(s)
      Kamon, T.; Shigeoka, D.; Tanaka, T.; Yoshimitsu, T.
    • Journal Title

      Org. Biomol. Chem

      Volume: 10 Pages: 2363-2365

    • Related Report
      2012 Final Research Report
  • [Journal Article] Stereoselective α-quaternization of 3-methoxycycloalk-2-enones via 1,4-diastereoinduction of alkoxy dienolates2012

    • Author(s)
      Moustafa, G. A. I.; Kamada, Y.; Tanaka, T.; Yoshimitsu, T.
    • Journal Title

      J. Org. Chem.

      Volume: 77 Pages: 1202-1207

    • Related Report
      2012 Final Research Report
  • [Journal Article] Pharmacokinetics of Agelastatin A in Central Nervous System2012

    • Author(s)
      Zhimin Li
    • Journal Title

      Med. Chem. Commun.

      Volume: 3 Issue: 2 Pages: 233-237

    • DOI

      10.1039/c1md00240f

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective alpha-quaternization of 3-methoxy cycloalk-2-enones via 1,4-diastereoinduction of alkoxy dienolates2012

    • Author(s)
      Gamal A. I. Moustafa
    • Journal Title

      J. Org. Chem.

      Volume: 77 Issue: 2 Pages: 1202-1207

    • DOI

      10.1021/jo2022789

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intramolecular iron(II)-catalyzed aminobromination of allyl N-tosyloxycarbamates2012

    • Author(s)
      Takuma Kamon
    • Journal Title

      Org. Biomol. Chem.

      Volume: 10 Issue: 12 Pages: 2363-2365

    • DOI

      10.1039/c2ob07190h

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetics of agelastatin A in central nervous system2011

    • Author(s)
      Li, Z.; Kamon, T.; Personett, D. A.; Caulfield, T.; Copland, J. A.; Yoshimitsu, T.; Tun, H. W.
    • Journal Title

      Med. Chem. Commun

      Volume: 3 Pages: 233-234

    • Related Report
      2012 Final Research Report
  • [Journal Article] Total synthesis of (±)-platencin2011

    • Author(s)
      Yoshimitsu, T.; Nojima, S.; Hashimoto, M.; Tanaka, T.
    • Journal Title

      Org. Lett.

      Volume: 13 Pages: 3698-3701

    • Related Report
      2012 Final Research Report
  • [Journal Article] Total synthesis of (±)-kainic acid: a photochemical C-H carbamoylation approach2011

    • Author(s)
      Kamon, T.; Irifune, Y.; Tanaka, T.; Yoshimitsu, T.
    • Journal Title

      Org. Lett.

      Volume: 13 Pages: 2674-2677

    • Related Report
      2012 Final Research Report
  • [Journal Article] Asymmetric total synthesis of (+)-danicalipin A2011

    • Author(s)
      Yoshimitsu, T.; Nakatani, R.; Kobayashi, A.; Tanaka, T.
    • Journal Title

      Org. Lett.

      Volume: 13 Pages: 908-911

    • Related Report
      2012 Final Research Report
  • [Journal Article] Total Synthesis of (±)-Platencin2011

    • Author(s)
      Takehiko Yoshimitsu
    • Journal Title

      Org. Lett.

      Volume: 13 Issue: 14 Pages: 3698-3701

    • DOI

      10.1021/ol2013439

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Total Synthesis of (+)-Danicalipin A2011

    • Author(s)
      Takehiko Yoshimitsu
    • Journal Title

      Org. Lett.

      Volume: 13 Issue: 5 Pages: 908-911

    • DOI

      10.1021/ol1029518

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of (±)-Kainic Acid: A Photochemical C-H Carbamoylation Approach2011

    • Author(s)
      Takuma Kamon
    • Journal Title

      Org. Lett.

      Volume: 13 Issue: 10 Pages: 2674-2677

    • DOI

      10.1021/ol200772f

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines2011

    • Author(s)
      Naoto Kojima
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 21 Issue: 19 Pages: 5745-5749

    • DOI

      10.1016/j.bmcl.2011.08.011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Total Synthesis of (+)-Danicalipin A2011

    • Author(s)
      Takehiko Yoshimitsu
    • Journal Title

      Org.Lett.

      Volume: 13 Pages: 908-911

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric total synthesis of (+)-hexachlorosulfolipid, a cytotoxin isolated from Adriatic mussels2010

    • Author(s)
      Yoshimitsu, T.; Fukumoto, N.; Nakatani, R.; Kojima, N.; Tanaka, T.
    • Journal Title

      J. Org. Chem

      Volume: 75 Pages: 5425-5437

    • Related Report
      2012 Final Research Report
  • [Journal Article] Asymmetric Total Synthesis of (+)-Hexachlorosulfolipid, a Cytotoxin Isolated from Adriatic Mussels2010

    • Author(s)
      Takehiko Yoshimitsu
    • Journal Title

      J.Org.Chem

      Volume: 75 Pages: 5425-5437

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Convergent Synthesis of Fluorescence-Labeled Probes of Annonaceous Acetogenins and Visualization of Their Cell Distribution2010

    • Author(s)
      Naoto Kojima
    • Journal Title

      Bioorg.Med.Chem.

      Volume: 18 Pages: 8630-8641

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Studies of the asymmetric total synthesis of clavilactone D by the 'Lariat' Cyclization Strategy2009

    • Author(s)
      Yoshimitsu, T.; Nojima, S.; Hashimoto, M.; Tsukamoto, K.; Tanaka, T.
    • Journal Title

      Synthesis

      Pages: 2963-2969

    • NAID

      130006997851

    • Related Report
      2012 Final Research Report
  • [Journal Article] Total synthesis of the ・-catenin inhibitor, (-)-agelastatin A: asecond-generation approach based on radical aminobromination2009

    • Author(s)
      Yoshimitsu, T.; Ino, T.; Futamura, N.; Kamon, T.; Tanaka, T.
    • Journal Title

      Org. Lett.

      Volume: 11 Pages: 3402-3405

    • Related Report
      2012 Final Research Report
  • [Journal Article] Studies of the Asymmetric Total Synthesis of Clavilactone D by the 'Lariat' Cyclization Strategy2009

    • Author(s)
      Takehiko Yoshimitsu
    • Journal Title

      Synthesis

      Pages: 2963-2969

    • NAID

      130006997851

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of the β-Catenin Inhibitor, (-)-Agelastatin A : A Second-Generation Approach Based on Radical Aminobromination2009

    • Author(s)
      Takehiko Yoshimitsu
    • Journal Title

      Org Lett. 11

      Pages: 3402-3405

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Chaetomellic Anhydride A, a Potent Inhibitor of Ras Protein Farnesyltransferase2009

    • Author(s)
      Takehiko Yoshimitsu
    • Journal Title

      Heterocycles 77

      Pages: 179-186

    • NAID

      40016405858

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enantiocontrolled Synthesis of Polychlorinated Hydrocarbon Motifs : A Nucleophilic Multiple Chlorination Process Revisited2009

    • Author(s)
      Takehiko Yoshimitsu
    • Journal Title

      J.Org.Chem. 74

      Pages: 696-702

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 遠隔立体誘起による立体収束的四級炭素構築2012

    • Author(s)
      鎌田泰正、 Moustafa A. I. Gamal、小島直人、田中徹明、好光健彦
    • Organizer
      第10回次世代を担う有機化学シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2012-05-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞増殖抑制天然物 agelastatin A 並びにその誘導体の化学合成と動態2012

    • Author(s)
      重岡大介、家門拓麻、河内崇志、荒井雅吉、小林資正、Li Z.、Caulfield T.、Qiu Y.、Tun H. W.、田中徹明、好光健彦
    • Organizer
      構造活性相関第38回反応と合成の進歩シンポジウム
    • Place of Presentation
      船橋
    • Related Report
      2012 Final Research Report
  • [Presentation] 特異な構造をもつ天然物の全合成-新しい不斉炭素構築法を中心に-2012

    • Author(s)
      好光健彦
    • Organizer
      九州大学大学院共通特論「先端有機化学」
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] ラジカル化学を基盤とする生物活性天然物の全合成2012

    • Author(s)
      好光健彦
    • Organizer
      九州大学先導物質化学研究所 講演会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Natural product synthesis via free radical chemistry2012

    • Author(s)
      Takehiko Yoshimitsu
    • Organizer
      The 6th Takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] (-)-Dysidiolide の形式全合成2012

    • Author(s)
      Moustafa A. I. Gamal、鎌田泰正、田中徹明、好光健彦
    • Organizer
      第29回有機合成化学セミナー
    • Place of Presentation
      静岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Radicals in Total Synthesis of Complex Molecules2012

    • Author(s)
      Takehiko Yoshimitsu
    • Organizer
      11th International Symposium on Organic Free Radicals
    • Place of Presentation
      Berne, Switzerland
    • Related Report
      2012 Final Research Report
  • [Presentation] Remote 1,4-stereoinduction strategy for the total synthesis of bioactive natural compounds bearing quaternary stereocenters2012

    • Author(s)
      Moustafa A. I. Gamal、Yasumasa Kamada、Tetsuaki Tanaka、Takehiko Yoshimitsu
    • Organizer
      The 7th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] 遠隔不斉誘起に基づく高ジアステレオ選択的四級炭素構築2012

    • Author(s)
      Gamal A. I. Moustafa、鎌田泰正、田中徹明、好光健彦
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 新規アミノハロゲン化手法の開発とアゲラスタチンの第三世代合成2012

    • Author(s)
      重岡大介、家門拓麻、田中徹明、 好光健彦
    • Organizer
      本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規アミノハロゲン化手法の開発とアゲラスタチンの第三世代合成2012

    • Author(s)
      重岡大介、好光健彦
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] カイニン酸の全合成2011

    • Author(s)
      家門拓麻、入船弥生、田中徹明、 好光健彦
    • Organizer
      第37回反応と合成の進歩シンポジウム
    • Place of Presentation
      徳島
    • Year and Date
      2011-11-07
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 触媒的アミノハロゲン化反応の開発とアゲラスタチンの第三世代全合成2011

    • Author(s)
      重岡大介、家門拓麻、田中徹明、 好光健彦
    • Organizer
      第61回日本薬学会近畿支部大会
    • Place of Presentation
      兵庫
    • Year and Date
      2011-10-22
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 1,4-不斉誘起による高立体選択的四級炭素構築と platencin の不斉全合成研究2011

    • Author(s)
      鎌田泰正、Gamal Moustafa、田中徹明、好光健彦
    • Organizer
      第61回日本薬学会近畿支部大会
    • Place of Presentation
      兵庫
    • Year and Date
      2011-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] カイニン酸の全合成2011

    • Author(s)
      家門拓麻、入船弥生、田中徹明、 好光健彦
    • Organizer
      第41回複素環化学討論会会
    • Place of Presentation
      熊本
    • Year and Date
      2011-10-20
    • Related Report
      2012 Final Research Report
  • [Presentation] カイニン酸の全合成2011

    • Author(s)
      家門拓麻、入船弥生、田中徹明、 好光健彦
    • Organizer
      第53回天然有機化合物討論会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-28
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 特異な構造を有する生物活性天然物の全合成2011

    • Author(s)
      好光健彦
    • Organizer
      日本薬学会東北支部 第10回化学系薬学若手研究者セミナー
    • Place of Presentation
      東北薬科大学
    • Year and Date
      2011-08-27
    • Related Report
      2012 Final Research Report
  • [Presentation] カイニン酸の全合成2011

    • Author(s)
      家門拓麻、入船弥生、田中徹明、 好光健彦
    • Organizer
      第9回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-05-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Danicalipin A の不斉全合成2011

    • Author(s)
      小林亮広、田中徹明、 好光健彦
    • Organizer
      日本薬学会第131 年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] Platencin の全合成2011

    • Author(s)
      能島梢司、橋本将志、田中徹明、 好光健彦
    • Organizer
      日本薬学会第131 年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] Danicalipin Aの不斉全合成2011

    • Author(s)
      小林亮広
    • Organizer
      第131回日本薬学会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] Platencinの全合成2011

    • Author(s)
      能島梢司
    • Organizer
      第131回日本薬学会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] カイニン酸の全合成研究2011

    • Author(s)
      家門拓麻、田中徹明、好光健彦
    • Organizer
      日本薬学会第131 年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] カイニン酸の全合成研究2011

    • Author(s)
      家門拓麻
    • Organizer
      第131回日本薬学会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラジカル化学を基盤とする天然物合成2011

    • Author(s)
      好光健彦
    • Organizer
      2011 年日本化学会 西日本大会
    • Place of Presentation
      徳島大学
    • Related Report
      2012 Final Research Report
  • [Presentation] ラジカル化学を基盤とする天然物合成2011

    • Author(s)
      好光健彦
    • Organizer
      2011年日本化学会 西日本大会
    • Place of Presentation
      徳島
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 1,4-不斉誘起による高立体選択的四級炭素構築とplatencinの不斉全合成研究2011

    • Author(s)
      鎌田泰正、好光健彦
    • Organizer
      第61回日本薬学会近畿支部大会
    • Place of Presentation
      兵庫
    • Related Report
      2011 Annual Research Report
  • [Presentation] カイニン酸の全合成2011

    • Author(s)
      家門拓麻、好光健彦
    • Organizer
      第41回複素環化学討論会
    • Place of Presentation
      熊本
    • Related Report
      2011 Annual Research Report
  • [Presentation] 特異な構造を有する生物活性天然物の全合成2011

    • Author(s)
      好光健彦
    • Organizer
      日本薬学会東北支部 第10回化学系薬学若手研究者セミナー
    • Place of Presentation
      仙台
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] カイニン酸の全合成研究2011

    • Author(s)
      家門拓麻、好光健彦
    • Organizer
      第9回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] (+)-Danicalipin Aの全合成2010

    • Author(s)
      小林亮広
    • Organizer
      第30回有機合成若手セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Platencin の全合成2010

    • Author(s)
      好光健彦、能島梢司、橋本将志、米本博敬、田中徹明
    • Organizer
      第36回反応と合成の進歩シンポジウム
    • Place of Presentation
      愛知
    • Year and Date
      2010-11-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Platencinの全合成2010

    • Author(s)
      能島梢司
    • Organizer
      第36回反応と合成の進歩シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] (+)-Danicalipin Aの全合成2010

    • Author(s)
      小林亮広
    • Organizer
      第60回日本薬学会近畿支部
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] ASYMMETRIC TOTAL SYNTHESIS OFCHLOROSULFOLIPIDS2010

    • Author(s)
      Takehiko Yoshimitsu, Naoya Fukumoto, Ryo Nakatani, Akihiro Kobayashi,Tetsuaki Tanaka
    • Organizer
      The 13th International Symposium on Marine Natural Products
    • Place of Presentation
      Phuket, Thailand
    • Year and Date
      2010-10-18
    • Related Report
      2012 Final Research Report
  • [Presentation] ASYMMETRIC TOTAL SYNTHESIS OF (-)-AGELASTATIN A2010

    • Author(s)
      Takehiko Yoshimitsu, Takuma Kamon, Tatsunori Ino, Tetsuaki Tanaka
    • Organizer
      The 13th International Symposium on Marine Natural Products
    • Place of Presentation
      Phuket, Thailand
    • Year and Date
      2010-10-18
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] ASYMMETRIC TOTAL SYNTHESIS OF CHLOROSULFOLIPIDS2010

    • Author(s)
      Akihiro Kobayashi
    • Organizer
      The 13th International Symposium on Marine Natural Products
    • Place of Presentation
      Phuket, Thailand
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] (-)-アゲラスタチン A の不斉全合成2010

    • Author(s)
      好光健彦、家門拓麻、伊野達徳、田中徹明
    • Organizer
      第40回複素環化学討論会
    • Place of Presentation
      宮城
    • Year and Date
      2010-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] クロロスルホリピッドの不斉全合成2010

    • Author(s)
      好光健彦
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      静岡
    • Year and Date
      2010-09-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] (□)□アゲラスタチンAの不斉全合成2010

    • Author(s)
      家門拓麻
    • Organizer
      第40回複素環化学討論会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] (-)-Agelastatin A の全合成2010

    • Author(s)
      好光健彦,家門拓麻,伊野達徳,田中徹明
    • Organizer
      第8回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-05-13
    • Related Report
      2012 Final Research Report
  • [Presentation] (-)-Agelastatin Aの全合成2010

    • Author(s)
      家門拓麻
    • Organizer
      第8回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-05-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 特異な構造を有する海洋産天然毒の不斉全合成2010

    • Author(s)
      好光健彦
    • Organizer
      名古屋市立大学薬学研究科大学院講義
    • Place of Presentation
      名古屋
    • Year and Date
      2010-05-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 高度に官能基化された海洋天然物の全合成2010

    • Author(s)
      好光健彦
    • Organizer
      日本薬学会東海支部特別講演会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-05-12
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 特異な構造を有する海洋産天然毒の不斉全合成2010

    • Author(s)
      好光健彦
    • Organizer
      名古屋市立大学薬学研究科大学講義
    • Place of Presentation
      名古屋
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] (-)-Agelastatin A の第二世代全合成2010

    • Author(s)
      好光健彦、家門拓麻、伊野達徳、田中徹明
    • Organizer
      日本薬学会第130 年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Platencin類の全合成研究2010

    • Author(s)
      好光健彦、橋本将志、田中徹明
    • Organizer
      日本薬学会第130 年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] (-)-Agelastatin A の第二世代全合成2010

    • Author(s)
      家門拓麻, 好光健彦
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Platencin 類の全合成研究2010

    • Author(s)
      橋本将志, 好光健彦
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Danicalipin Aの不斉全合成研究2010

    • Author(s)
      仲谷陵, 好光健彦
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Total Synthesis of Bioactive Marine Natural Products Directed toward the Discovery of New Anticancer Drugs2010

    • Author(s)
      T akehiko Yoshimitsu
    • Organizer
      Invited as a 2009 ACP lectureship Award recipient
    • Place of Presentation
      Chulabhorn Research Institute (CRI), Thailand
    • Year and Date
      2010-01-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Total Synthesis of Bioactive Marine Natural Products Directed toward the Discovery of New Anticancer Drugs2010

    • Author(s)
      好光健彦
    • Organizer
      Invited as a 2009 ACP lectureship Award recipient (Asian CORE program for Cutting-Edge Organic Chemistry)
    • Place of Presentation
      Chulabhorn Research Institute (CRI), Bangkok, Thailand
    • Year and Date
      2010-01-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Total Synthesis of Bioactive Marine Natural Products Directed toward the Discovery of New Anticancer Drugs2010

    • Author(s)
      Takehiko Y oshimitsu
    • Organizer
      Invited as a 2009 ACP lectureship Award recipient
    • Place of Presentation
      Ramkhamhaeng University, Thailand
    • Year and Date
      2010-01-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Total Synthesis of Bioactive Marine Natural Products Directed toward the Discovery of New Anticancer Drugs2010

    • Author(s)
      好光健彦
    • Organizer
      Invited as a 2009 ACP lectureship Award recipient (Asian CORE program for Cutting-Edge Organic Chemistry)
    • Place of Presentation
      Ramkhamhaeng University, Bangkok, Thailand
    • Year and Date
      2010-01-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Total Synthesis of Bioactive Marine Natural Products Directed toward the Discovery of New Anticancer Drugs2010

    • Author(s)
      Takehiko Yoshimitsu
    • Organizer
      Invited as a 2009 ACP lectureship Award recipient
    • Place of Presentation
      Chulalongkorn University, Thailand
    • Year and Date
      2010-01-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Total Synthesis of Bioactive Marine Natural Products Directed toward the Discovery of New Anticancer Drugs2010

    • Author(s)
      好光健彦
    • Organizer
      Invited as a 2009 ACP lectureship Award recipient (Asian CORE program for Cutting-Edge Organic Chemistry)
    • Place of Presentation
      Chulalongkorn University, Bangkok, Thailand
    • Year and Date
      2010-01-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Total Synthesis of Bioactive Marine Natural Products Directed toward the Discovery of New Anticancer Drugs2010

    • Author(s)
      Takehiko Yoshimitsu
    • Organizer
      Invited as a 2009 ACP lectureship Award recipient
    • Place of Presentation
      Mahidol University, Thailand
    • Year and Date
      2010-01-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Total Synthesis of Bioactive Marine Natural Products Directed toward the Discovery of New Anticancer Drugs2010

    • Author(s)
      好光健彦
    • Organizer
      Invited as a 2009 ACP lectureship Award recipient (Asian CORE program for Cutting-Edge Organic Chemistry)
    • Place of Presentation
      Mahidol University, Bangkok, Thailand
    • Year and Date
      2010-01-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 渡環型反応点制御を鍵とする Clavilactone D の不斉全合成研究2009

    • Author(s)
      能島梢司, 好光健彦
    • Organizer
      第35回反応と合成の進歩シンポジウム
    • Place of Presentation
      石川
    • Year and Date
      2009-11-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヘキサクロロスルホリピッド danicalipin A の不斉全合成研究2009

    • Author(s)
      仲谷陵, 好光健彦
    • Organizer
      第59回日本薬学会近畿支部
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] (-)-Agelastatin A の第二世代全合成2009

    • Author(s)
      家門拓麻, 好光健彦
    • Organizer
      第59回日本薬学会近畿支部
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Total synthesis of (-)-agelastatin A toward the discovery of new anticancer agents2009

    • Author(s)
      Takehiko Yoshimitsu, Tatsunori Ino, Takuma Kamon, Tetsuaki Tanaka
    • Organizer
      IKCOC-11 (The 11th International Kyoto Conference on New Aspects of Organic Chemistry)
    • Place of Presentation
      京都
    • Year and Date
      2009-11-11
    • Related Report
      2012 Final Research Report 2009 Annual Research Report
  • [Presentation] (-)-Agelastatin A の第二世代全合成2009

    • Author(s)
      好光健彦、家門拓麻、伊野達徳、田中徹明
    • Organizer
      第59回日本薬学会近畿支部
    • Place of Presentation
      近畿大学
    • Year and Date
      2009-10-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 生物活性海洋天然物の全合成2009

    • Author(s)
      好光健彦
    • Organizer
      有機合成協会東海支部有機合成セミナー
    • Place of Presentation
      静岡県立大学
    • Year and Date
      2009-09-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 生物活性海洋天然物の全合成2009

    • Author(s)
      好光健彦
    • Organizer
      有機合成協会東海支部有機合成セミナー
    • Place of Presentation
      静岡
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗腫瘍活性天然物(-)-Agelastatin A の全合成と活性評価2009

    • Author(s)
      好光健彦
    • Organizer
      第8回「生理活性をあまり意図しない自由な天然物合成勉強会」
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report 2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b002/

    • Related Report
      2010 Annual Research Report
  • [Remarks] (1) 阪大研究者総覧

    • URL

      http://www.dma.jim.osaka-u.ac.jp/kg-portal/aspI/RX0011D.asp?UNO=14944&page=

    • Related Report
      2009 Annual Research Report
  • [Remarks] (2) 所属研究室ホームページ

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b002/

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 研究成果有体物移転・使用契約締結MTA11-113:アゲラスタチン2011

    • Industrial Property Rights Holder
      エーザイ株式会社 オンコロジー創薬ユニット
    • Filing Date
      2011-11-15
    • Related Report
      2012 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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