Discovery and Development of Antitumor Compounds from Marine Dinoflagellates
| Project/Area Number |
21590011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kochi University |
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Principal Investigator |
TSUDA Masashi 高知大学, 教育研究部・総合科学系, 教授 (10261322)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 渦鞭毛藻 / 殺細胞活性 / 二次代謝産物 |
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| Research Abstract |
Our investigation for new anticancer drug leads from the dinoflagellate Amphidinium sp., we have resulted in the isolation of several cytotoxic polyketide, amphirionins-2 and-3 and caribenolide-I from a marine dinoflagellate Amphidinium sp. Their structure elucidation were carried out using detailed analyses of spectroscopic data such as 2D NMR spectra and MS data.
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Report
(4 results)
Research Products
(38 results)
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[Presentation] Amphirionin-2, a Novel Cytotoxic Polyketide from Dinofragellate Amphiclinium Species," Nataarma : Naure Aided Drug Aisovery"(NADD),2011
Author(s)
Kumagai K., Akakabe M., Minamida M., Tsuda M., Konishi Y., Tominaga A.
Organizer
Conference Centre of the University" Federico II"
Place of Presentation
Aula Magna Partenope, Napoli, Italy
Related Report
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