Development of versatile 1, 2-Diamine synthetic methodology and its application for preparation of drug candidates.
Project/Area Number |
21590013
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Kumamoto University |
Principal Investigator |
ISHIZUKA Tadao 熊本大学, 大学院・生命科学研究部, 教授 (60176203)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 有機化学 / ジアミン / diamine / imidazolone / imidazolidinone / 不斉合成 / 不斉補助剤 / 合成子 |
Research Abstract |
Synthetic strategy for chiral 1, 2-diamines, which are included in many kind of bioactive compounds, has been successfully developed. The versatile chiral synthon, 4, 5-dimethoxy-2-imidazolidinone, has been prepared by FeCl_3 catalized epoxidation-ring cleavage with H_2O or t-BuOH process followed by optical resolution. Diastereomeric methodology with camphor-derived chiral carboxylic acid has also successed with 93% de.
|
Report
(4 results)
Research Products
(9 results)