Development of heterogeneous palladium on carbon-catalyzed aromatic amination
Project/Area Number |
21590014
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Gifu Pharmaceutical University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | (細目表キーワード)有機化学 / パラジウム炭素 / 不均一系触媒 / 芳香族アミノ化反応 / 環境負荷低減 / 有機化学 / 機能性物質 / 合成化学 / 触媒・化学プロセス |
Research Abstract |
Heterogeneous palladium on carbon(Pd/C)-catalyzed cross-coupling between amines and aromatic halides was developed.(Pd/C was quantitatively recovered and palladium species were hardly leached into the reaction media. Furthermore, intramolecular aromatic amination of 2-bromophenetylamine was found to proceed to afford the corresponding indoline. The reaction at higher temperature led to a quantitative aromatization of indoline to indole
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Report
(4 results)
Research Products
(9 results)