SOLVENT-FREE AND COMPLETE SOLID-PHASE CATALYSIS USING SOLID CATALYST・SOLID SUBSTRATE・SOLID REAGENTS
| Project/Area Number |
21590015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MONGUCHI Yasunari 岐阜薬科大学, 薬学部, 准教授 (40433205)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 固体触媒 / 固相触媒反応 / 接触還元 / 鈴木-宮浦反応 / パラジウム / プロセス化学 / 無溶媒 / 混合 / プロセル化学 / プロセス化学無溶媒 |
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| Research Abstract |
The solvent-free and solid-phase hydrogenation of various reducible functionalities was efficiently catalyzed by heterogeneous palladium on carbon(Pd/C) under ambient hydrogen pressure and temperature without any liquid materials. The Pd/C-catalyzed Suzuki? Miyaura coupling reaction between solid arylbromides and solid arylboronic acids in the presence of solid Pd/C and Cs2CO3 or K2CO3 leading to the formation of solid biaryls has also been efficiently achieved under the absolute solid-phase conditions.
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Report
(4 results)
Research Products
(16 results)
