SOLVENT-FREE AND COMPLETE SOLID-PHASE CATALYSIS USING SOLID CATALYST・SOLID SUBSTRATE・SOLID REAGENTS

• Project/Area Number: 21590015
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Gifu Pharmaceutical University
• Principal Investigator: SAJIKI Hironao 岐阜薬科大学, 薬学部, 教授 (50275096)
• Co-Investigator(Kenkyū-buntansha): MONGUCHI Yasunari 岐阜薬科大学, 薬学部, 准教授 (40433205)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 固体触媒 / 固相触媒反応 / 接触還元 / 鈴木-宮浦反応 / パラジウム / プロセス化学 / 無溶媒 / 混合 / プロセル化学 / プロセス化学無溶媒

Research Abstract

The solvent-free and solid-phase hydrogenation of various reducible functionalities was efficiently catalyzed by heterogeneous palladium on carbon(Pd/C) under ambient hydrogen pressure and temperature without any liquid materials. The Pd/C-catalyzed Suzuki? Miyaura coupling reaction between solid arylbromides and solid arylboronic acids in the presence of solid Pd/C and Cs2CO3 or K2CO3 leading to the formation of solid biaryls has also been efficiently achieved under the absolute solid-phase conditions.

Research Products

• [Journal Article] Carbon-Carbon Bond Formation by Ligand-free Cross-Coupling Reaction Using Palladium Catalyst Supported on Synthetic Adsorbent (2012)
  • Author(s): Yasunari Monguchi, Keita Sakai, Koichi Endo, Yuki Fujita, Masaru Niimura, Masatoshi Yoshimura, Tomoteru Mizusaki, Yoshinari Sawama, Hironao Sajiki
  • Journal Title: Chem Cat Chem Volume: 4 Issue: 4 Pages: 546-558
  • DOI: 10.1002/cctc.201100345
  • Peer Reviewed
• [Journal Article] Solvent-Free Hydrogenation and Suzuki-Miyaura Coupling Using Pd/C (2012)
  • Author(s): Yasuhiro Uozumi, Toshihisa Suzuka
  • Journal Title: Synfacts Volume: 8 Pages: 113-113
  • URL: https://www.thieme-connect.com/ejournals/toc/synfacts/107922
• [Journal Article] Palladium on carbon-catalyzed solvent-free and solid-phase hydrogenation and Suzuki-Miyaura reaction (2011)
  • Author(s): Yasunari Monguchi, Yuki Fujita, Shota Hashimoto, Mariko Ina, Tohru Takahashi, Ryo Ito, Kei Nozaki, Tomohiro Maegawa, Hironao Sajiki
  • Journal Title: Tetrahedron Volume: 67 Issue: 45 Pages: 8628-8634
  • DOI: 10.1016/j.tet.2011.09.043
  • Peer Reviewed
• [Presentation] 担持型白金族触媒を利用した不均一系C-C及びC-N結合形成反応の開発 (2012)
  • Author(s): 佐治木弘尚
  • Organizer: CPhI Japan国際医薬品原料・中間体展TLO/大学知的財産本部技術移転セミナー
  • Place of Presentation: 東京
  • Year and Date: 2012-03-21
• [Presentation] 合成吸着剤を担体とした機能性白金族触媒の開発研究 (2012)
  • Author(s): 佐治木弘尚
  • Organizer: CPhI Japan国際医薬品原料・中間体展プロセス化学セミナー
  • Place of Presentation: 東京
  • Year and Date: 2012-03-21
• [Presentation] 均一系白金族触媒の機能多様性:既存の触媒に潜む新しい触媒活性の開拓と新規機能性触媒の開発 (2011)
  • Author(s): 佐治木弘尚
  • Organizer: 三重大学大学院工学研究科特別講演会
  • Place of Presentation: 津
  • Year and Date: 2011-12-16
• [Presentation] 不均一系白金族触媒の機能多様性:既存の触媒に潜む新しい触媒活性の開拓と新規機能性触媒の開発 (2011)
  • Author(s): 佐治木弘尚
  • Organizer: 三重大学大学院工学研究科特別講演会
  • Place of Presentation: 津
  • Year and Date: 2011-12-16
• [Presentation] 合成吸着剤を担体とした機能性白金族触媒の開発研究 (2011)
  • Author(s): 門口泰也
  • Organizer: 第6回プロセス化学ラウンジ
  • Place of Presentation: 熱海
• [Presentation] 不均一系触媒の新機軸新しい有機合成手法と触媒の開発 (2010)
  • Author(s): 佐治木弘尚
  • Organizer: 日本薬学会北陸支部特別講演会
  • Place of Presentation: 金沢
  • Year and Date: 2010-05-25
• [Presentation] 効率的金属触媒を用いた新しい有機合成反応手法の開発 (2010)
  • Author(s): 佐治木弘尚
  • Organizer: CPHIJAPNA2010(第9回国際医薬品原料・中間体展)
  • Place of Presentation: 東京
  • Year and Date: 2010-04-21
• [Presentation] 効率的金属触媒を用いた新しい有機合成反応手法の開発 (2010)
  • Author(s): 佐治木弘尚
  • Organizer: CPHI JAPNA2010(第9回国際医薬品原料・中間体点)
  • Place of Presentation: 東京
  • Year and Date: 2010-04-21
• [Presentation] 不均一系白金族触媒による新しい有機合成反応手法の開発 (2009)
  • Author(s): 佐治木弘尚
  • Organizer: 第3回ECOケミストリー研究会
  • Place of Presentation: 和歌山
  • Year and Date: 2009-11-19
• [Presentation] 不均一系触媒のモデルチェンジ-既存の不均一系触媒に新しい機能を吹き込みます- (2009)
  • Author(s): 佐治木弘尚
  • Organizer: セミナー"化学千一夜"「あすの化学への夢を語ろう」
  • Place of Presentation: 大津
  • Year and Date: 2009-06-13
• [Presentation] 不均一系白金族触媒を利用した効率的有機合成反応の開発 (2009)
  • Author(s): 佐治木弘尚
  • Organizer: 大阪大学大学院薬学研究科講演会
  • Place of Presentation: 大阪
  • Year and Date: 2009-06-08
• [Presentation] 不均一経白金族触媒の新機軸 (2009)
  • Author(s): 佐治木弘尚
  • Organizer: CPhI JAPAN 2009(第8回国際医薬品原料・中間体展)
  • Place of Presentation: 東京
  • Year and Date: 2009-04-21
• [Remarks]
  • URL: http://www.gifu-pu.ac.jp/lab/yakuhin/index.html