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Development of novel sugar-related organic compounds utilized for the elucidation of life phenomenon.

Research Project

Project/Area Number 21590021
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionTeikyo University

Principal Investigator

TAKAHASHI Hideyo  帝京大学, 薬学部, 教授 (10266348)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords糖 / エーテル結合糖 / 糖尿病 / 糖鎖 / レベッカマイシン / グリコシル化 / SAM法 / PA化法 / Coyolosa / オキシラン
Research Abstract

In order to elucidate life phenomenon, novel sugar-related compounds(e. g., ether-linked sugars, Rebeccamycin derivatives) were efficiently synthesized. A new analytical method, which is utilizing SAM : Self-Assembled Monolayers, was also developed and was used for biological investigation.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2011 2010 2009

All Journal Article (14 results) (of which Peer Reviewed: 13 results) Presentation (5 results)

  • [Journal Article] Sugar-binding properties of the two lectin domains of LEC-1 with respect to the Gal. 1-4Fuc disaccharide unit present in protostomia glycoconjugates2011

    • Author(s)
      Takeuchi, Tomoharu ; Sugiura, Ken-ichi ; Nishiyama, Kazusa ; Takahashi, Hideyo ; Natsugari, Hideaki ; Arata, Yoichiro ; Kasai, Ken-ichi
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume: 34 Pages: 1134-1138

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caenorhabditis elegans proteins captured by immobilized Gal-4Fuc disaccharide units : assignment of 3 annexins2011

    • Author(s)
      Takeuchi, Tomoharu ; Takahashi, Hideyo, 他8名
    • Journal Title

      Carbohydrate Research

      Volume: 346 Pages: 1837-1841

    • Related Report
      2011 Final Research Report
  • [Journal Article] β-galactosidases from Jack Bean and Streptococcus have different cleaving abilities towards fucose-containing sugars2011

    • Author(s)
      Takeuchi, Tomoharu ; Sugiura, Ken-ichi ; Nishiyama, Kazusa ; Takahashi, Hideyo ; Natsugari, Hideaki ; Arata, Yoichiro ; Natsuka, Shunji ; Kasai, Ken-ichi
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume: 34 Pages: 567-569

    • NAID

      120005520798

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The DC2.3 gene in Caenorhabditis elegans encodes galecctin that recognizes the galactose. 1-4Fucose disaccharide unit2011

    • Author(s)
      Nemoto-sasaki, Yoko ; Takai, Shunsuke ; Takeuchi, Tomoharu ; Arata, Yoichiro ; Nishiyama, Kazusa ; Takahashi, Hideyo ; Natsugari, Hideaki ; Kasai, Ken-ichi
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Pages: 1635-1639

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of new Gal. 1-4Fuc segments useful for biological investigations2011

    • Author(s)
      Nishiyama, Kazusa ; Yamada, Atsushi ; Takeuchi, Tomoharu ; Arata, Yoichiro ; Kasai, Ken-ichi ; Oshitari, Tetsuta ; Natsugari, Hideaki ; Takahashi, Hideyo
    • Journal Title

      Chemical & Pharmaceutical Bulletin

      Pages: 1307-1310

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The DC2.3 gene in Caenorhabditis elegans encodes galectin that recognizes the galactose β1-4 fucose disaccharide unit2011

    • Author(s)
      Nemoto-Sasaki, Yoko
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume: 34 Pages: 1635-1639

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sugar-binding properties of the two lectin domains of LEC-1 with respect to the Galb1-4Fuc disaccharide unit present in protostomia glycoconjugates2011

    • Author(s)
      Takeuchi, Tomoharu
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume: 34 Pages: 1134-1138

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caenorhabditis elegans proteins captured by immobilized Galβ1-4Fuc disaccharide units: Assignment of 3 annexins2011

    • Author(s)
      Takeuchi, Tomoharu
    • Journal Title

      Carbohydrate Research

      Volume: 346 Issue: 13 Pages: 1837

    • DOI

      10.1016/j.carres.2011.05.012

    • NAID

      120005518442

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of fluorescence-labeled Gal. 1-4Fuc as probes for the endogenous glycol-epitope recognized by galectins in Caenorhabditis elegans2010

    • Author(s)
      Nishiyama, Kazusa ; Yamada, Atsushi ; Takahashi, Miki ; Takeuchi, Tomoharu ; Kasai, Ken-ichi ; Kobayashi, Susumu ; Natsugari, Hideaki ; Takahashi, Hideyo
    • Journal Title

      Chemical & Pharmaceutical Bulletin

      Volume: 58 Pages: 495-500

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of fluorescence-labeled Galβ1-3Fuc and Galβ1-4Fuc as probes for the endogenous glyco-epitope recognized by galectins in Caenorhabdit is elegans2010

    • Author(s)
      Hideyo Takahashi, et al.
    • Journal Title

      Chemical & Pharmaceutical Bulletin

      Volume: 58 Pages: 495-500

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel glycosidation of α-D-altropyranoside2010

    • Author(s)
      Takahiro Nakayama
    • Journal Title

      Synthesis

      Pages: 43-48

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caenorhabditis elegans galectins LEC-6 and LEC-1 recognize a chemically synthesized Gal. 1-4Fuc disaccharide unit which is present in Protostomia glycoconjugates2009

    • Author(s)
      Takeuchi, Tomoharu ; Nishiyama, Kazusa ; Sugiura, Ken-ichi ; Takahashi, Miki ; Yamada, Atsushi ; Kobayashi, Susumu ; Takahashi, Hideyo ; Natsugari, Hideaki ; Kasai, Ken-ichi
    • Journal Title

      Glycobiology

      Volume: 19 Pages: 1503-1510

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of trimannoside-recognizing peptide sequences from a T7 phage deisplay screen using a QCM device2009

    • Author(s)
      Nishiyama, Kazusa ; Takakusagi, Yoichi ; Kusayanagi, Tomoe ; Matsumoto, Yuki ; Habu, Shiori ; Kuramochi, Kouji ; Sugawara, Fumio ; Sakaguchi, Kengo ; Takahashi, Hideyo ; Natsugari, Hideaki ; Kobayashi, Susumu
    • Journal Title

      Bioloorganic & Medicinal Chemistry

      Volume: 17 Pages: 195-202

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caenorhabditis elegans galectins LEC-6 and LEC-1 recognize a chemically synthesized Galβ1-4Fuc disaccharide unit which is present in protostomia glycoconjugates2009

    • Author(s)
      Tomoharu Takeuchi
    • Journal Title

      Glycobiology Vol.19

      Pages: 1503-1510

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Galβ1-4Fuc分子プローブの合成及び糖結合性タンパク質の探索2011

    • Author(s)
      西山和沙
    • Organizer
      第61回有機合成化学協会関東支部シンポジウム
    • Place of Presentation
      千葉大学(千葉県)
    • Year and Date
      2011-05-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 線虫内在性糖鎖の分子プローブ化及び標的タンパク質の探索2011

    • Author(s)
      西山和沙、山田篤、武内智春、草柳友恵、松本勇記、高草木洋一、菅原二三男、坂口謙吾、小林進、笠井献一、夏苅英昭、高橋秀依
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 線虫ガレクチンLEC-6による糖鎖認識機構解明のための分子プロ-ブの合成及びその評価2010

    • Author(s)
      西山和沙、山田篤、武内智春、草柳友恵、松本勇記、高草木洋一、菅原二三男、坂口謙互、小林進、笠井献一、夏苅英昭、高橋秀依
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      静岡
    • Year and Date
      2010-09-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 医薬品と軸不斉2010

    • Author(s)
      高橋秀依
    • Organizer
      有機合成化学協会関東支部談話会
    • Place of Presentation
      和光純薬湯河原研修所(神奈川県)
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Galβ(1-4)Fuc固定化アフィニティカラムの作成及びガレクチン結合能の検討2009

    • Author(s)
      山田篤
    • Organizer
      第53回日本薬学会関東支部大会
    • Place of Presentation
      城西大学薬学部(埼玉県)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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