Development of efficient synthetic route for marine natural compound
| Project/Area Number |
21590024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
ITO Hisanaka 東京薬科大学, 生命科学部, 教授 (70287457)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 合成化学 / 全合成 / 天然物 / 生理活性 |
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| Research Abstract |
Synthetic study of yonarolide was examined. Yonarolide, a norditerpenoid having tetracyclic skeleton, was isolated from Okinawan soft coral. Development of an efficient and stereoselective construction of the left tricyclic skeleton was achieved through Diels-Alder reaction and following stereoselective intramolecular aldol condensation via an epimerization by reversible Michael reaction.
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Report
(4 results)
Research Products
(5 results)
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[Presentation] Synthetic study of yonarolide2009
Author(s)
Yohei Ueda, Kazuo Iguchi, and Hisanaka Ito
Organizer
11^<th> International Kyoto Conference on New Aspects of Organic Chemistry(IKCOC-11)
Place of Presentation
京都
Year and Date
2009-11-11
Related Report
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