| Project/Area Number |
21590025
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
KONAKAHARA Takeo 東京理科大学, 理工学部・工業化学科, 教授 (80084333)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Norio (IKEDA Norio) 東京理科大学, 理工学部, 准教授 (00328569)
SAKAI Reiko 東京理科大学, 理工学部, 助教 (60516441)
NAKAIKE Yumi 東京理科大学, 理工学部, 助教 (10579775)
KIRAN Y. b. 東京理科大学, 理工学部, PD (50468708)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 抗腫瘍剤 / β-カルボリン / エリプチシン / ピリジン / ピリミジン / アポトーシス / ヘテロ環 / フルオラス |
|---|
| Research Abstract |
We have succeeded to develop a series of new.-carboline derivatives, which shows practically-potent antitumor activity for HeLa S-3 cell line. This compound is a new type of an antitumor agent to induce apoptosis via interaction with.-tublin. In addition, we have succeeded to develop a new and effective synthetic method for the synthesis of ellipticine using Suzuki-Miyaura coupling reaction, and to develop new methods for construction of pyridine, pyrimidine, pyrrole, pyridone, and quinolone rings, which are expected as frameworks for a new type of antitumor agents.
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