Synthesis of Highly-Functional DNA Binding Indole Alkaloids and Quinolones and Their Antitumor Activity
| Project/Area Number |
21590025
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
KONAKAHARA Takeo 東京理科大学, 理工学部・工業化学科, 教授 (80084333)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Norio (IKEDA Norio) 東京理科大学, 理工学部, 准教授 (00328569)
SAKAI Reiko 東京理科大学, 理工学部, 助教 (60516441)
NAKAIKE Yumi 東京理科大学, 理工学部, 助教 (10579775)
KIRAN Y. b. 東京理科大学, 理工学部, PD (50468708)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 抗腫瘍剤 / β-カルボリン / エリプチシン / ピリジン / ピリミジン / アポトーシス / ヘテロ環 / フルオラス |
|---|
| Research Abstract |
We have succeeded to develop a series of new.-carboline derivatives, which shows practically-potent antitumor activity for HeLa S-3 cell line. This compound is a new type of an antitumor agent to induce apoptosis via interaction with.-tublin. In addition, we have succeeded to develop a new and effective synthetic method for the synthesis of ellipticine using Suzuki-Miyaura coupling reaction, and to develop new methods for construction of pyridine, pyrimidine, pyrrole, pyridone, and quinolone rings, which are expected as frameworks for a new type of antitumor agents.
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Report
(4 results)
Research Products
(149 results)
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[Journal Article] 3-(3-Phenoxybenzyl) amino-υ-carboline : A novel antitumor drug targettingτ-tubulin2011
Author(s)
Reiko Ikeda, Masaki Kurosawa, Takazumi Okabayashi, Ayako Takee, Masamichi Yoshiwara, Tadashi Kumakura, Norio Sakai, Osamu Funatsu, Akinori Morita, Masahiko Ikekita, Yumi Nakaike, Takeo Konakahara
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Journal Title
Bioorg. Med. Chem. Lett
Volume: 21
Pages: 4784-4787
Related Report
Peer Reviewed
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[Journal Article] 3-(3-Phenoxybenzyl) amino-β-carboline : A novel antitumor drug targeting α-tubulin2011
Author(s)
Reiko Ikeda, Masaki Kurosawa, Takazumi Okabayashi, Ayako Takee, Masamichi Yoshiwara, Tadashi Kumakura, Norio Sakai, Osamu Funatsu, Akinori Morita, Masahiko Ikekita, Yumi Nakaike, Takeo Konakahara
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Journal Title
Bioorg.Med.Chem.Lett.
Volume: 21
Issue: 16
Pages: 4784-4787
DOI
Related Report
Peer Reviewed
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[Journal Article] Synthesis of 12,12a-dihydro-7,12a-diazacyclohepta[cd]benz[g]azulen-12-one (cyclohepta[m, n]pyrrolo[2,1-c][1,4]benzodiazepin-12-one) and evaluation of cytotoxic activity against HeLa S3 cells2011
Author(s)
Eiko Yoshioka, Hiroyuki Fujii, Toshinobu Murafuji, Reiko Ikeda, Takeo Konakahara, Takahiro Gunji, Noritaka Abe
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Journal Title
HETEROCYCLES
Volume: 83
Issue: 11
Pages: 140-1415
DOI
Related Report
Peer Reviewed
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