Construction of CD-Sensitive Porphyrin Tweezer Systems and Their Application for the Direct Sensing of Chiral Organic Molecules
| Project/Area Number |
21590027
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Meiji Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | ビスポルフィリン / 円二色性 / 絶対配置 / ホスト分子 / 超分子 / 分散型CDスペクトル / CD励起子法 / 不斉認識 / レセプター分子 / 不斉認識能 / SNAr反応 / 光学活性アミン / 分散性CDスペクトル / 絶対配置決定 / 光学活性アルコール / 非対応称ポルフィリン / 根岸クロスカップリング / 光学活性ジアミン / 光学活性ジオール / 非対称ポルフィリン |
|---|
| Research Abstract |
Design, synthesis, and chirogenetic properties of novel pseudo-cofacial zinc porphyrin tweezers as an efficient circular dichroism(CD)-sensitive host molecule were explored. The notable features of the new tweezer systems are their facile synthetic accessibility and high binding affinity for a variety of optically active molecules, including diols, alcohols, and epoxides as well as amines, diamines, and aminoalcohols, providing an efficient direct, non-empirical determination of absolute configuration of these substrates at room temperature without the need for chemical derivatization.
|
Report
(4 results)
Research Products
(40 results)
-
-
-
-
-
[Journal Article] Highly Regioselective Rearrangement of 2, 3-Diaryloxiranes into 2, 2-Diarylacetaldehydes Catalyzed by Ytterbium Porphyrin Complex, Yb(TPP) OTf2009
Author(s)
T. Takanami, S. Nakajima, S. Nakadai, F. T. Takanami, S. Nakajima, S. Nakadai, F. Hino, K. Suda
-
Journal Title
Heterocycles
Volume: 77
Issue: 1
Pages: 365-374
DOI
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
