| Project/Area Number |
21590027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ビスポルフィリン / 円二色性 / 絶対配置 / ホスト分子 / 超分子 / 分散型CDスペクトル / CD励起子法 / 不斉認識 / レセプター分子 / 不斉認識能 / SNAr反応 / 光学活性アミン / 分散性CDスペクトル / 絶対配置決定 / 光学活性アルコール / 非対応称ポルフィリン / 根岸クロスカップリング / 光学活性ジアミン / 光学活性ジオール / 非対称ポルフィリン |
|---|
| Research Abstract |
Design, synthesis, and chirogenetic properties of novel pseudo-cofacial zinc porphyrin tweezers as an efficient circular dichroism(CD)-sensitive host molecule were explored. The notable features of the new tweezer systems are their facile synthetic accessibility and high binding affinity for a variety of optically active molecules, including diols, alcohols, and epoxides as well as amines, diamines, and aminoalcohols, providing an efficient direct, non-empirical determination of absolute configuration of these substrates at room temperature without the need for chemical derivatization.
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