| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
1) Asymmetric total synthesis of the natural products, furctigenine A, okaramine M, verrucofortine, N-acetylardeemin and so on, was achieved on the basis of developing stereoselective construction of quaternary carbon center and Ugi reaction-cyclization. 2) The structure-activity relationship study was performed by synthesis of some derivatives of N-acetylardeemin, inhibited reversal of multiple drug resistance for anti-cancer agents, and their evaluation of P-glycoprotain inhibitory activity. 3) Stereoselective construction of vicinal quaternary carbon centers was developed to construct a fundamental carbon framework of chimonanthines.
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