Synthetic Studies on Bioactive Polycyclic Ethers
| Project/Area Number |
21590029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
MORI Yuji 名城大学, 薬学部, 教授 (40121511)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ポリ環状エーテル / 全合成 / ガンビエロール / シガテラ毒 / 神経毒 / 海洋天然物 / ポリテトラヒドロピラン / 収束合成 / オキシラニルアニオン / Gambierdiscus toxicus / gambierol / 環拡大反応 / 海洋ポリエーテル / 海洋毒 / シガテラ / 6-エンド閉環反応 |
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| Research Abstract |
Ciguatera poisoning is a toxicological syndrome resulting from the ingestion of seafood contaminated by certain toxic polycyclic ethers produced by the epiphytic dinoflagellate Gambierdiscus toxicus. The toxin suite comprises ciguatoxins, maitotoxin, and gambierol. Gambierol consists of a ladder-shaped trans-fused octacyclic ring system with 18 stereogenic centers. The total synthesis of gambierol has been achieved utilizing an oxiranyl anion strategy in an iterative manner. The synthetic route includes direct carbon. carbon formation on epoxides, sulfonyl. assisted 6.endo cyclization, and ring expansion reaction of tetrahydropyranyl rings to oxepanes to forge the polycyclic skeleton of the target molecule.
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Report
(4 results)
Research Products
(44 results)
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[Presentation] Total Synthesis of Gambierol2009
Author(s)
Yuki Hasegawa, Hiroki Furuta, Yuji Mori
Organizer
The 11^<th> International Kyoto Conference on New Aspect of Organic Chemistry(IKCOC-11)
Place of Presentation
京都
Year and Date
2009-11-11
Related Report
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[Presentation] Total synthesis of gambierol2009
Author(s)
Yuki Hasegawa, Hiroki Furuta, Yuji Mori
Organizer
The 6^<th> Nagoya-Nanjing-Shenyang Symposium of Pharmaceutical Sciences
Place of Presentation
名古屋
Year and Date
2009-09-14
Related Report
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[Presentation] ガンビエロールの全合成2009
Author(s)
古田大貴、長谷川裕基、森裕二
Organizer
第55回(平成21年度)日本薬学会東海支部大会
Place of Presentation
名古屋
Year and Date
2009-07-11
Related Report
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