New evolution of continuous hetero-atomic chemistry
Project/Area Number |
21590034
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Kobe Pharmaceutical University |
Principal Investigator |
MIYATA Okiko 神戸薬科大学, 薬学部, 教授 (90102110)
|
Co-Investigator(Kenkyū-buntansha) |
UEDA Masafumi 神戸薬科大学, 薬学部, 講師 (00340935)
MIYOSHI Tetsuya 神戸薬科大学, 薬学部, 助手 (10549992)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 合成化学 / オキシムエーテル / アルコキシアミン / 複素環化合物 / 極性転換反応 / エナミン / イソキサゾール / アルキン / ベンズアミド / ドミノ反応 / キノリン / マルチネリン |
Research Abstract |
The oxime ether and the alkoxy amines where the nitrogen atom and the oxygen atom existed continuously were selected as the functional group bearing as consecutive hetero atoms. The continuous multistage reaction of these compounds with low environmental load was developed, and highly efficient and versatile synthetic methods of the heterocyclic compounds contained in a lot of medicines and the biologically active compounds were established. In addition, new polarity inversed reactions of the carbonyl compounds were developed by using these functional groups as an innovative method for carbon-carbon bond formation.
|
Report
(4 results)
Research Products
(43 results)