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Synthesis of macrocyclic compounds that change their conformation depending on the external environment of stimulus

Research Project

Project/Area Number 21590035
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionTokushima Bunri University

Principal Investigator

AZUMAYA Isao  徳島文理大学, 香川薬学部, 教授 (50276755)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsMcMurry coupling / ジアゾ化合物 / 分子認識 / 環境応答分子 / 環状分子 / 外部環境応答 / 機能性材料 / 分子包接 / 立体配座 / 大環状化合物 / 芳香族アミド / アゾベンゼン / 単結晶X線構造解析
Research Abstract

In this project, large macrocyclic compounds that could change the size of the cavity depending on the external environment or stimulus were synthesized. The macrocyclic compound which contains the amide linkages changed its conformation by chemical introduction or removal of alkyl groups on the amide nitrogens. Furthermore, the macrocyclic compound which contains the azo linkages changed its conformation by irradiating of UV light or heating.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2011 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (15 results) Remarks (2 results)

  • [Journal Article] Calix[3] amide-based Anion Receptors : High Affinity for Fluoride Ions and a Twisted Binding Model2011

    • Author(s)
      Katagiri, K.; Furuyama, T.; Masu, H.; Kato, T.; Matsumura, M.; Uchiyama, M.; Tanatani, A.; Tominaga, M.; Kagechika, H.; Yamaguchi, K.; Azumaya, I.
    • Journal Title

      Supramolecular Chemistry

      Volume: 23巻 Issue: 1-2 Pages: 125-130

    • DOI

      10.1080/10610278.2010.514909

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphism or Pseudopolymorphism of a Macrocyclic Compound : Helical Structure, Layered Structure, and Pseudorotaxane Constructed by Weak Intermolecular Interactions2010

    • Author(s)
      Tohaya, T.; Katagiri, K.; Katoh, J.; Masu, H.; Tominaga, M.; Azumaya, I.
    • Journal Title

      CrystEng Comm

      Volume: 12巻 Issue: 11 Pages: 3493-3495

    • DOI

      10.1039/c0ce00058b

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphism or Pseudopolymorphism of a Macrocyclic Compound : Helical Structure, Layered Structure, and Pseudorotaxane Constructed by Weak Intermolecular Interactions.2010

    • Author(s)
      Tohaya, T.; Katagiri, K.; Katoh, J.; Masu, H.; Tominaga, M.; Azumaya, I.
    • Journal Title

      CrystEngCommun

      Volume: 12 Pages: 3493-3495

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 芳香族環状トリアミドのカプセル型二量体形成と分子不斉2011

    • Author(s)
      松村実生, 藤本慎子, 桝飛雄真, 片桐幸輔, 東屋功, 影近弘之, 棚谷綾
    • Organizer
      第20回有機結晶シンポジウム
    • Place of Presentation
      富山
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Construction of Characteristic Crystal Structure using Polymorphism or Pseudopolymorphism2011

    • Author(s)
      東屋功
    • Organizer
      第14回アジア化学会議
    • Place of Presentation
      バンコク、タイ
    • Year and Date
      2011-09-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Construction of Characteristic Crystal Structure using Polymorphism or Pseudopolymorphism2011

    • Author(s)
      東屋功
    • Organizer
      第14回アジア化学会議
    • Place of Presentation
      バンコク,タイ(招待)
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spontaneous Resolution of Aromatic Amides and Sulfonamides Having No Fixed Chiral Element2011

    • Author(s)
      東屋功
    • Organizer
      BIT's 2^<nd> Annual World Congress of Catalytic Asymmetric Synthesis 2011
    • Place of Presentation
      北京,中国(招待)
    • Year and Date
      2011-08-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] マクマリー反応による一段階環化生成物を経由する縮環系芳香族化合物の合成2011

    • Author(s)
      尾畑亮介、戸早太一、片桐幸輔、富永昌英、東屋功
    • Organizer
      第91回日本化学会年会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 芳香族アミドの立体特性を利用した環状化合物の合成2011

    • Author(s)
      園川麻衣、池島規雄、片桐幸輔、富永昌英、東屋功
    • Organizer
      第91回日本化学会年会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] マクマリー反応による-段階環化生成物を経由する縮環系芳香族化合物の合成2011

    • Author(s)
      東屋功、戸早太一、尾畑亮介、片桐幸輔、富永昌英
    • Organizer
      日本化学会第91春季大会
    • Place of Presentation
      神奈川
    • Related Report
      2010 Annual Research Report
  • [Presentation] 芳香族アミドの立体特性を利用した環状化合物の合成2011

    • Author(s)
      園川麻衣、池島規雄、片桐幸輔、富永昌英、東屋功
    • Organizer
      日本化学会第91春季大会
    • Place of Presentation
      神奈川
    • Related Report
      2010 Annual Research Report
  • [Presentation] 共役系芳香族を基本骨格にもつ芳香族スルホンアミドの合成と構造解析2011

    • Author(s)
      加藤潤也、片桐幸輔、富永昌英、東屋功
    • Organizer
      日本化学会第91春季大会
    • Place of Presentation
      神奈川
    • Related Report
      2010 Annual Research Report
  • [Presentation] McMurry coupling を利用した大環状化合物の合成と構造2010

    • Author(s)
      戸早太一
    • Organizer
      第90回日本化学会年会
    • Place of Presentation
      近畿大学(大阪)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] McMurry Couplingを利用した大環状化合物の合成と構造2010

    • Author(s)
      戸早太一、加藤潤也、片桐幸輔、桝飛雄真、富永昌英、東屋功
    • Organizer
      第90回日本化学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 特徴的なナノ構造を形成するブロック分子のデザインおよび合成2009

    • Author(s)
      東屋功
    • Organizer
      有機合成化学協会九州山口支部平成21年度第二回講演会
    • Place of Presentation
      長崎
    • Year and Date
      2009-11-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 結晶多形・擬似結晶多形現象を用いた結晶内分子配列制御2009

    • Author(s)
      東屋功
    • Organizer
      第18回有機結晶シンポジウム
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2009-11-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] McMurry coupling を利用した大環状化合物の合成と結晶構造2009

    • Author(s)
      戸早太一
    • Organizer
      第20回基礎有機化学討論会
    • Place of Presentation
      群馬大学(群馬)
    • Year and Date
      2009-09-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] McMurry couplingを利用した大環状化合物の合成と結晶構造2009

    • Author(s)
      戸早太一、加藤潤也、片桐幸輔、桝飛雄真、富永昌英、東屋功
    • Organizer
      第20回基礎有機化学討論会
    • Place of Presentation
      群馬
    • Year and Date
      2009-09-28
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://kp.bunri-u.ac.jp/poc/

    • Related Report
      2011 Final Research Report
  • [Remarks] 作成中

    • URL

      http://kp.bunri-u.ac.jp/poc/page2.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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