Analysis of Modification with polyamines and investigation of the physiological significance
Project/Area Number |
21590044
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Physical pharmacy
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Research Institution | Josai University |
Principal Investigator |
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | ポリアミン / 分子修飾 / 腸管吸収 / アシル基転移反応 / アシルスペルミン / N-acyltransferase (NAT) / スペルミン / アシルアミン / N-acyltransferase(NAT) / ポイアミンアナログ / ポリアミンアナログ |
Research Abstract |
In this study, polyamines that remain to be resolved for detailed roles, was focused to investigate novel cellular functions. The results illustrated that the transfer of polyamines to acyl group occurred during the acyl transfer reaction between cellular phospholipids. Additionally, polyamine-conjugated compounds were found to affect intestinal absorption of water-soluble big molecules.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells2012
Author(s)
Nayvelt I, John S, Hsu HC, Yang P, Liu W, Das G, Hyvonen MT, Alhonen L, Keinanen TA, Shirahata A, Patel R, Thomas T, Thomas TJ
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Journal Title
Amino Acids
Volume: (in press)
Issue: 2-3
Pages: 899-911
DOI
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Peer Reviewed
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[Presentation] Polyamine analogs affect neurite outgrowth and cellular response of PC12 cells2009
Author(s)
Ikeguchi, Y., Tashiro, D., Okazaki, M., Tani, S., Tanaka, T., Hibino, Y. and Shirahata, A.
Organizer
Gordon Research Conference on Polyamines 2009
Place of Presentation
米国
Related Report
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[Presentation] Effect of Polyamine Synthase Inhibitor on Adipogenesis of 3T3-L1 cells2009
Author(s)
Ishii, I., Ikeguchi, Y., Yamazaki, K., Wada, M., Mano, H., Pegg, A. E. and Shirahata, A.
Organizer
2009 Gordon Research Seminar on Polyamines及びGordon Research Conference on Polyamines
Place of Presentation
米国
Related Report
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