Wide-range log P_<o/w> estimation of drug-related compounds by flow-injection analysis combined with a novel two-phase solvent partitioning
| Project/Area Number |
21590047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
YANAGIDA Akio 東京薬科大学, 薬学部, 准教授 (40318192)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBUSAWA Yoichi 東京薬科大学, 薬学部, 教授 (10102708)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 分析化学 / log P / オクタノール/水二相溶媒系 / FIA / アミノ酸 / 核酸 / 薬物 / オクタノール / 分配係数 / 二相溶媒系 / 高極性化合物 / ペプチド / 液体クロマトグラフィー / フローインジェクション分析 / 向流クロマトグラフィー |
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| Research Abstract |
High-throughput method for measuring a partition coefficient(K) of highly hydrophobic and/or hydrophilic compound was established by flow-injection analysis(FIA) combined with novel two-phase solvent partitioning. The measured K values of 51 kinds of standard compounds, especially their log K values were closely related to their(literature-based) log P(P : partition coefficient between octanol/water two-phase system) values. The relationship between the log P and the log K values was expressed as the correlating equation "log P=2.849×log K-0.1576". Therefore the combination of the K measurement by FIA and the correlating equation enable to estimate a wide-range log P values(+8～-8) of a huge variety of compounds from their measured log K values(+3～-3). In this study, the estimated log P values of highly polar amino acids, peptides, nucleotides were obtained by the above method.
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Report
(4 results)
Research Products
(8 results)
