Manipulation of gastrointestinal functions by polymeric conjugates bearing glucosides, oral anti-diabetic drugs
| Project/Area Number |
21590051
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Setsunan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Shinji 摂南大学, 薬学部, 教授 (00158156)
玉井 郁巳 金沢大学, 薬学系, 教授 (20155237)
AKASHI Mitsuru 大阪大学, 工学研究科, 教授 (20145460)
木田 敏之 大阪大学, 工学研究科, 准教授 (20234297)
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| Co-Investigator(Renkei-kenkyūsha) |
KIDA Toshiyuki 大阪大学, 工学研究科, 准教授 (20234297)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 高分子複合体 / 配糖体 / 糖尿病 / ヘキソーストランスポーター / インクレチン / デンドリマー / SGLT1 / GLP-1 / 消化管 / 糖鎖 |
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| Research Abstract |
Carbohydrates in the human diet are hydrolyzed by digestive enzymes in the gastrointestinal tract. The resulting monosaccharides, such as glucose, are absorbed from the small intestine via influx hexose transporters, mainly sodium-dependent Na+/glucose cotransporters(SGLT1). Carbohydrates also induce the secretion of glucagon-like peptide 1(GLP-1) from intestinal L cells. Insulin secretion is subsequently enhanced by GLP-1 because this peptide stimulates ss cells in pancreas. Polymeric conjugates bearing glucosides were synthesized and their abilities for SGLT1 inhibition and induction of GLP-1 secretion were examined. We successfully proved that carboxyl group-terminated polyamidoamine dendrimers bearing arbutin was a potential candidate as oral anti-diabetic drugs having above-mentioned abilities.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake2010
Author(s)
Shinji Sakuma, Yumi Teraoka, Tomokazu Sagawa, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Yusuke Ikumi, Toshiyuki Kida, Mitsuru Akashi
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Journal Title
Eur. J. Pharm. Biopharm
Volume: 75(3)
Pages: 366-374
Related Report
Peer Reviewed
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[Journal Article] Involvement of functional groups on the surface of carboxyl group-terminated polyamidoamine dendrimers bearing arbutin in inhibition of Na+/glucose cotransporter 1(SGLT1)-mediated D-glucose uptake
Author(s)
Shinji Sakuma, Shun Kanamitsu, Yumi Teraoka, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Masahiro Muraoka, Yohji Nakatsuji, Toshiyuki Kida, Mitsuru Akashi
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Journal Title
Mol. Pharmaceutics
Volume: (in press)
Related Report
Peer Reviewed
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[Presentation] 消化管膜機能制御に基づく抗糖尿病作用を有する配糖体-高分子複合体の精密設計2012
Author(s)
佐久間信至, 金光俊, 寺岡裕美, 政岡祥江, 片岡誠, 山下伸二, 白坂善之, 玉井郁巳, 村岡雅弘, 中辻洋司, 木田敏之, 明石満
Organizer
日本薬学会第132年会
Place of Presentation
札幌
Year and Date
2012-03-30
Related Report
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[Presentation] Inhibitory effect of arbutin conjugated to polyamidoamine dendrimers on intestinal glucose transport2011
Author(s)
Shun Kanamitsu, Shinji Sakuma, Yumi Teraoka, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Masahiro Muraoka, Yohji Nakatsuji, Toshiyuki Kida, Mitsuru Akashi
Organizer
International Symposium on BA/BE of Oral Drug Products
Place of Presentation
Kobe, Japan
Year and Date
2011-06-30
Related Report
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[Presentation] デンドリマー型アルブチンの化学構造とSGLT1(Na+/糖共輸送体)の阻害活性との相関の検証2011
Author(s)
金光俊, 佐久間信至, 寺岡裕美, 政岡祥江, 片岡誠, 山下伸二, 白坂善之, 玉井郁巳, 村岡雅弘, 中辻洋司, 木田敏之, 明石満
Organizer
第27回日本DDS学会
Place of Presentation
東京
Year and Date
2011-06-09
Related Report
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