| Project/Area Number |
21590051
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Setsunan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Shinji 摂南大学, 薬学部, 教授 (00158156)
玉井 郁巳 金沢大学, 薬学系, 教授 (20155237)
AKASHI Mitsuru 大阪大学, 工学研究科, 教授 (20145460)
木田 敏之 大阪大学, 工学研究科, 准教授 (20234297)
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| Co-Investigator(Renkei-kenkyūsha) |
KIDA Toshiyuki 大阪大学, 工学研究科, 准教授 (20234297)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 高分子複合体 / 配糖体 / 糖尿病 / ヘキソーストランスポーター / インクレチン / デンドリマー / SGLT1 / GLP-1 / 消化管 / 糖鎖 |
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| Research Abstract |
Carbohydrates in the human diet are hydrolyzed by digestive enzymes in the gastrointestinal tract. The resulting monosaccharides, such as glucose, are absorbed from the small intestine via influx hexose transporters, mainly sodium-dependent Na+/glucose cotransporters(SGLT1). Carbohydrates also induce the secretion of glucagon-like peptide 1(GLP-1) from intestinal L cells. Insulin secretion is subsequently enhanced by GLP-1 because this peptide stimulates ss cells in pancreas. Polymeric conjugates bearing glucosides were synthesized and their abilities for SGLT1 inhibition and induction of GLP-1 secretion were examined. We successfully proved that carboxyl group-terminated polyamidoamine dendrimers bearing arbutin was a potential candidate as oral anti-diabetic drugs having above-mentioned abilities.
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