Development of New Liquid Chromatography with Separation-oriented Derivatization of Biological Compounds and Its Application to Biomedical Analysis
| Project/Area Number |
21590053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Hideyuki 福岡大学, 薬学部, 准教授 (20301690)
TODOROKI Kenichiro 静岡県立大学, 薬学部, 准教授 (70341451)
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| Research Collaborator |
SAKAGUCHI Yohei 福岡大学, 大学院・薬学研究科, 博士
IKENAGA Jun 福岡大学, 大学院・薬学研究科, 博士
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 分析化学 / クロマトグラフィー / 誘導体化分析 / 生体計測 / フルオラス化学 / 分離分析 / 蛍光分析 / 質量分析 / 分離 |
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| Research Abstract |
Liquid chromatography(LC) with separation-oriented derivatization of biological compounds has been developed as a new and simple analysis methodology. Experimental results indicate that the fluorous-phase LC column can selectively retain fluorous compounds including fluorous-labeled analytes on the basis of fluorous-fluorous interaction. We believe that separation-oriented derivatization presented here is the first step toward the introduction of fluorous derivatization in quantitative LC analysis.
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Report
(4 results)
Research Products
(115 results)
