Study on the serum protein-mediated drug transport in biological membrane interface
| Project/Area Number |
21590054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OTAGIRI Masaki 崇城大学, 薬学部, 教授 (80120145)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 膜インターフェイス / 血清アルブミン / 薬物輸送 / α_1-酸性糖タンパク質 |
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| Research Abstract |
This study was undertaken to evaluate serum protein-mediated drug transport. Through the investigation of the interaction between human serum albumin(HSA) and tissue cells, we explored the specific mechanism that HSA is incorporated and change its conformation so that the bound drug is released. In addition, our data suggests that HSA is incorporated into liver parenchymal cell via clathrin-medicated endocytosis.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Characterization of the hepatic cellular uptake of α1-acid glycoprotein(AGP), part 1 : a peptide moiety of human AGP is recognized by the hemoglobinβ-chain on mouse liver parenchymal cells2012
Author(s)
Nishi K, Komori H, Kikuchi M, Uehara N, Fukunaga N, Matsumoto K, Watanabe H, Nakajou K, Misumi S, Suenaga A, Maruyama T, Otagiri M
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Journal Title
J. Pharm. Sci
Volume: 101
Pages: 1599-1606
Related Report
Peer Reviewed
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