Glycomic approaches for the identification of tumor-associated glycoproteins as potential tumor markers
| Project/Area Number |
21590056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
KAWASAKI Nana 国立医薬品食品衛生研究所, 生物薬品部, 部長 (20186167)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 癌 / 糖鎖 / グライコミクス / プロテオミクス |
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| Research Abstract |
Previously we suggested that heterogeneous nuclear ribonucleoproteins(hnRNPs) could be carrier proteins of sialyl Lewis x(sLe^x) glycoepitope which is widely used as a tumor marker. In this study we demonstrated that some hnRNPs were co-localized with sLe^x in Golgi apparatus, and their levels were up-regulated during S/G2 phases of the cell cycles. Furthermore, we found that expression of sLe^x was up-regulated by Fuc-T VI, and inhibition of Fuc-T VI expression suppressed the proliferation of colorectal cancer cell lines. These results suggested that sLe^x and hnRNP might be associated with the proliferation of colorectal cells and some hnRNPs could be used as novel tumor makers.
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Report
(4 results)
Research Products
(9 results)
