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Glycomic approaches for the identification of tumor-associated glycoproteins as potential tumor markers

Research Project

Project/Area Number 21590056
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical pharmacy
Research InstitutionNational Institute of Health Sciences

Principal Investigator

KAWASAKI Nana  国立医薬品食品衛生研究所, 生物薬品部, 部長 (20186167)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords癌 / 糖鎖 / グライコミクス / プロテオミクス
Research Abstract

Previously we suggested that heterogeneous nuclear ribonucleoproteins(hnRNPs) could be carrier proteins of sialyl Lewis x(sLe^x) glycoepitope which is widely used as a tumor marker. In this study we demonstrated that some hnRNPs were co-localized with sLe^x in Golgi apparatus, and their levels were up-regulated during S/G2 phases of the cell cycles. Furthermore, we found that expression of sLe^x was up-regulated by Fuc-T VI, and inhibition of Fuc-T VI expression suppressed the proliferation of colorectal cancer cell lines. These results suggested that sLe^x and hnRNP might be associated with the proliferation of colorectal cells and some hnRNPs could be used as novel tumor makers.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2012 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (3 results)

  • [Journal Article] The status ofα1-3/4 fucosylation at Asn 241 ofβ-haptoglobin is associated with colon cancer progression : A top-down and bottom-up combinatorial approach2012

    • Author(s)
      Seung-Yeol Park, Sung-Hyeon Lee, Keunsoo Kang, Nana Kawasaki, Satsuki Itoh, Noritaka Hashii, Jin-Man Kim, Ji-Yeon Kim, Seon-Joo Yoon, and Jung Hoe Kim
    • Journal Title

      Int. J. Cancer

      Volume: Vol.130 Pages: 2366-2376

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The status of α1-3/4 fucosylation at Asn 241 of β-haptoglobin is associated with colon cancer progression : A top-down and bottom-up combinatorial approach2012

    • Author(s)
      Seung-Yeol Park, Sung-Hyeon Lee, Keunsoo Kang, Nana Kawasaki, Satsuki Itoh, Noritaka Hashii, Jin-Man Kim, Ji-Yeon Kim, Seon-Joo Yoon, Jung Hoe Kim
    • Journal Title

      Int.J.Cancer.

      Volume: 130 Pages: 2366-76

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 糖鎖関連医薬品の開発と分析化学2010

    • Author(s)
      川崎ナナ
    • Journal Title

      ぶんせき

      Volume: 421巻 Pages: 17-22

    • NAID

      10026786426

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 糖鎖関連医薬品の開発と分析化学2010

    • Author(s)
      川崎ナナ
    • Journal Title

      ぶんせき 421

      Pages: 17-22

    • NAID

      10026786426

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of glycoproteins carrying a target glycan-motif by liquid chromatography/multiple-stage mass spectrometry. Identification of Lewis x-glycoproteins in mouse kidney2009

    • Author(s)
      Hashii, N., Kawasaki, N., et al
    • Journal Title

      J. Proteome Res.

      Volume: Vol.8 Pages: 3415-3429

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of glycoproteins carrying a target glycan-motif by liquid chromatography/multiple-stage mass spectrometry. Identification of Lewis x-glycoproteins in mouse kidney2009

    • Author(s)
      Hashii, N., Kawasaki, N., et al.
    • Journal Title

      J.Proteome Res. 8

      Pages: 3415-3429

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 創薬におけるグライコミクスアプローチ2011

    • Author(s)
      川崎ナナ、橋井則貴、伊藤さつき、中澤志織
    • Organizer
      日本薬学会第131年会・創薬を加速する次世代プロテオミクスの多面的アプローチ
    • Place of Presentation
      静岡
    • Related Report
      2011 Final Research Report
  • [Presentation] 創薬におけるグライコミクスアプローチ2011

    • Author(s)
      川崎ナナ、橋井則貴、伊藤さつき、中澤志織
    • Organizer
      日本薬学会第131年会創薬を加速する次世代プロテオミクスの多面的アプローチ
    • Place of Presentation
      静岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of nuclear sialyl lewis x-conjugated glycoproteins in the proliferation of cancer cell lines2009

    • Author(s)
      Takakura, D., Kawasaki, N., et al
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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