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Analysis of the roles of cyclin D1 in breast cancer stem cells

Research Project

Project/Area Number 21590081
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionNigata University of Phermacy and Applied Life Sciences

Principal Investigator

SAKAMAKI Toshiyuki  新潟薬科大学, 薬学部, 准教授 (00445892)

Co-Investigator(Kenkyū-buntansha) SATO Koji  新潟薬科大学, 薬学部, 助教 (10445893)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords遺伝子 / 癌 / 細胞・組織 / シグナル伝達 / 蛋白質
Research Abstract

Cyclin D1 induces the expression of Dnmt1, Dnmt3a and Dnmt3b, and increases methylation in the promoter region of Musashi1.These results demonstrate that Cyclin D1 may play an important role in tumorigenesis of breast stem cells by epigenetically affecting Notch1 signaling through Musashi1.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results) Remarks (2 results)

  • [Journal Article] ErbB2 down-regulates microRNA-205 in breast cancer2011

    • Author(s)
      Adachi R, Horiuchi S, Sakurazawa Y, Hasegawa T, Sato K, Sakamaki T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: Vol.41 Issue: 4 Pages: 804-808

    • DOI

      10.1016/j.bbrc.2011.07.033

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion2010

    • Author(s)
      Liu M, Sakamaki T, Pestell RG., 他12名
    • Journal Title

      Cancer Res

      Volume: Vol.70 Issue: 24 Pages: 10464-10473

    • DOI

      10.1158/0008-5472.can-10-0732

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion.2010

    • Author(s)
      Manran Liu
    • Journal Title

      Cancer Research

      Volume: 70 Pages: 10464-10473

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo2009

    • Author(s)
      Liu M, Sakamaki T, Pestell RG., 他11名
    • Journal Title

      Am J Pathol

      Volume: Vol.174 Issue: 5 Pages: 1910-1920

    • DOI

      10.2353/ajpath.2009.080706

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo.2009

    • Author(s)
      Manran Liu
    • Journal Title

      The American Journal of Pathology 174

      Pages: 1910-1920

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ErbB2 down-regulates microRNA-205 in breast cancer2011

    • Author(s)
      Toshiyuki Sakamaki
    • Organizer
      EPS Anticancer drugs 2011 in Sweden
    • Place of Presentation
      Kival Hotel (Stockholm)(招待講演)
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] ErbB2 down-regulates microRNA-205 in breast cancer2011

    • Author(s)
      Sakamaki T.
    • Organizer
      EPS Anticancer drugs 2011
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2011 Final Research Report
  • [Presentation] ErbB2過剰発現乳癌におけるhsa-miR-205の役割の解析2011

    • Author(s)
      安達亮平、堀内翔太、櫻澤喜之、佐藤浩二、酒巻利行
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://202.244.210.151/nuphp/KgApp

    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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