Analysis of the roles of cyclin D1 in breast cancer stem cells

• Project/Area Number: 21590081
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Nigata University of Phermacy and Applied Life Sciences
• Principal Investigator: SAKAMAKI Toshiyuki 新潟薬科大学, 薬学部, 准教授 (00445892)
• Co-Investigator(Kenkyū-buntansha): SATO Koji 新潟薬科大学, 薬学部, 助教 (10445893)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 遺伝子 / 癌 / 細胞・組織 / シグナル伝達 / 蛋白質

Research Abstract

Cyclin D1 induces the expression of Dnmt1, Dnmt3a and Dnmt3b, and increases methylation in the promoter region of Musashi1.These results demonstrate that Cyclin D1 may play an important role in tumorigenesis of breast stem cells by epigenetically affecting Notch1 signaling through Musashi1.

Research Products

• [Journal Article] ErbB2 down-regulates microRNA-205 in breast cancer (2011)
  • Author(s): Adachi R, Horiuchi S, Sakurazawa Y, Hasegawa T, Sato K, Sakamaki T
  • Journal Title: Biochem Biophys Res Commun Volume: Vol.41 Issue: 4 Pages: 804-808
  • DOI: 10.1016/j.bbrc.2011.07.033
  • Peer Reviewed
• [Journal Article] The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion (2010)
  • Author(s): Liu M, Sakamaki T, Pestell RG., 他12名
  • Journal Title: Cancer Res Volume: Vol.70 Issue: 24 Pages: 10464-10473
  • DOI: 10.1158/0008-5472.can-10-0732
  • Peer Reviewed
• [Journal Article] The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion. (2010)
  • Author(s): Manran Liu
  • Journal Title: Cancer Research Volume: 70 Pages: 10464-10473
  • Peer Reviewed
• [Journal Article] Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo (2009)
  • Author(s): Liu M, Sakamaki T, Pestell RG., 他11名
  • Journal Title: Am J Pathol Volume: Vol.174 Issue: 5 Pages: 1910-1920
  • DOI: 10.2353/ajpath.2009.080706
  • Peer Reviewed
• [Journal Article] Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo. (2009)
  • Author(s): Manran Liu
  • Journal Title: The American Journal of Pathology 174 Pages: 1910-1920
  • Peer Reviewed
• [Presentation] ErbB2 down-regulates microRNA-205 in breast cancer (2011)
  • Author(s): Toshiyuki Sakamaki
  • Organizer: EPS Anticancer drugs 2011 in Sweden
  • Place of Presentation: Kival Hotel (Stockholm)(招待講演)
  • Year and Date: 2011-10-27
• [Presentation] ErbB2 down-regulates microRNA-205 in breast cancer (2011)
  • Author(s): Sakamaki T.
  • Organizer: EPS Anticancer drugs 2011
  • Place of Presentation: Stockholm, Sweden
• [Presentation] ErbB2過剰発現乳癌におけるhsa-miR-205の役割の解析 (2011)
  • Author(s): 安達亮平、堀内翔太、櫻澤喜之、佐藤浩二、酒巻利行
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Remarks]
• [Remarks]
  • URL: http://202.244.210.151/nuphp/KgApp