Analysis of the roles of cyclin D1 in breast cancer stem cells
| Project/Area Number |
21590081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Koji 新潟薬科大学, 薬学部, 助教 (10445893)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 遺伝子 / 癌 / 細胞・組織 / シグナル伝達 / 蛋白質 |
|---|
| Research Abstract |
Cyclin D1 induces the expression of Dnmt1, Dnmt3a and Dnmt3b, and increases methylation in the promoter region of Musashi1.These results demonstrate that Cyclin D1 may play an important role in tumorigenesis of breast stem cells by epigenetically affecting Notch1 signaling through Musashi1.
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Report
(4 results)
Research Products
(10 results)
