| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We identified an endogenous ligand, Hsp70 for an oxidized LDL receptor, FEEL and demonstrated that FEEL is implicated in innate immunity. Then, we identified SNX17 as a binding protein to cytoplasmic domain of FEEL and demonstrated that SNX17 is implicatedin the processing and stability of FEELprotein. Using knockout mice for FEEL, we found the contribution of FELL to lipoprotein metabolism. Using FEEL and apoE double-knockout mice, we found FEEL is implicated in the development of atherosclerotic regions.
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