| Project/Area Number |
21590090
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Itaru 群馬大学, 生体調節研究所, 教授 (60143492)
OSHIMA Yoshiteru 東北大学, 大学院・薬学研究科, 教授 (00111302)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 細胞性粘菌 / 分化誘導因子 / がん / 糖尿病 / 免疫 / トリパノソーマ / DIF |
|---|
| Research Abstract |
Dictyostelium differentiation-inducing factor DIF-1 and its derivatives (DIFs) are low-molecular weight compounds that possess anti-tumor and glucose-consumption-promoting activities. In this study, we performed comprehensive study on DIFs and have found the followings ; 1) DIF-1 inhibits mitochondrial malate dehydrogenase activity, 2) some DIF derivatives inhibit the invasion of a mouse osteosarcoma in vitro, 3) DIF-1 affects TCA cycle, 4) DIFs possess novel pharmacological activities, such as regulation of IL-2 production in T cells, induction of cardiomyocytes differentiation, and inhibition of Trypanosoma cell growth, and 5) DIFs can regulate Dictyostelium chemotaxis.
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