Study on transcriptional activation mechanism of DJ-1 gene(PARK7) and the trial to Parkinson's disease cure development
Project/Area Number |
21590091
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | University of Yamanashi |
Principal Investigator |
TAIRA Takahiro 山梨大学, 大学院・医学工学総合研究部, 教授 (70197036)
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Co-Investigator(Kenkyū-buntansha) |
OHGA Rie 山梨大学, 医学部, 助手 (00160432)
FUJIMURO Masahiro 山梨大学, 大学院・医学工学総合研究部, 准教授 (20360927)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | DJ-1 / パーキンソン病 / 酸化ストレス / 神経変性疾患 / 転写調節 / 神経細胞 / 神経膠細胞 / 細胞死 / アストロサイト / 癌遺伝子 |
Research Abstract |
The DJ-1 protein which is a familial Parkinson's disease(PARK7) causative gene product. It was already shown clearly that DJ-1 protein is associated with tyrosine hydroxylase(TH). Although it had been unknown the mechanism of transcriptional activation of TH gene by DJ-1 protein. In this research, We clarified trans-activation mechanism TH gene by DJ-1 protein. Also among human, mouse and rat, it was shown clearly that a mechanism has a difference.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] The protocadherins, PCDHB1 and PCDH7, are regulated by MeCP2 in neuronal cells and brain tissues : implication for pathogenesis of Rett syndrome2011
Author(s)
Miyake K, Hirasawa T, Soutome M, Itoh M, Goto Y, Endoh K, Takahashi K, Kudo S, Nakagawa T, Yokoi S, Taira T, Inazawa J, Kubota T.
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Journal Title
BMC Neurosci
Volume: 8 ; 12
Pages: 81-81
Related Report
Peer Reviewed
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[Journal Article] Protection against dopaminergic neurodegeneration in Parkinson's disease-model animals by amodulator of the oxidized form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK72011
Author(s)
Inden M, Kitamura Y, Takahashi K, Takata K, Ito N, Niwa R, Funayama R, Nishimura K, Taniguchi T, Honda T, Taira T, Ariga H.
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Journal Title
J Pharmacol Sci
Volume: 117(3)
Pages: 189-203
Related Report
Peer Reviewed
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[Journal Article] Protection Against Dopaminergic Neurodegeneration in Parkinson's Disease-Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson's Disease-Linked PARK72011
Author(s)
Inden, M., Kitamura, M., Takahashi, K., Takata, K., Ito, N., Niwa, R., Funayama, R., Nishimura, K., Taniguchi, T., Honda, T., Taira, T., Ariga, H.
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Journal Title
Journal of Pharmacological Sciences
Volume: 117
Issue: 3
Pages: 189-203
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed
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[Journal Article] Oxidative neurodegeneration is prevented by UCP0045037, an allosteric modulator for the reduced form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK72009
Author(s)
Yamane, K., Kitamura, Y., Yanagida, T., Takata, T., Yanagisawa, D., Taniguchi, T., Taira, T. and Ariga, H.
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Journal Title
Int. J. Mol. Sci
Volume: 10(11)
Pages: 4789-4804
NAID
Related Report
Peer Reviewed
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[Journal Article] S. M. M.(2009) DJ-1 binds to mitochondrial complex I and maintains its activity.2009
Author(s)
Hayashi, T., Ishimori, C., Takahashi-Niki, K., Taira, T., Kim, Y-C., Maita, H., Maita, C., Ariga, H. and Iguchi-Ariga
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 390
Pages: 667-672
Related Report
Peer Reviewed
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[Journal Article] S. M. M.(2009) Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and4-dihydroxy-1-phenylalanine(1-DOPA) decarboxylase with DJ-12009
Author(s)
Ishikawa, S., Taira, T., Niki, T., Takahashi-Niki, K., Maita, C., Maita, H., Ariga, H. and Iguchi-Ariga
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Journal Title
J. Biol. Chem
Volume: 284
Pages: 28832-28844
Related Report
Peer Reviewed
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[Journal Article] Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice2009
Author(s)
Inden, M., Kitamura, Y., Tamaki, A., Yanagida, T., Shibaike, T., Yamamoto, A., Takata, K., Yasui, H., Taira, T., Ariga, H. and Taniguchi, T.
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Journal Title
Neurochem. Int
Volume: 55(8)
Pages: 760-767
Related Report
Peer Reviewed
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[Journal Article] Protection against oxida tive stress-induced neurodegeneration by amodulator for DJ-1, a wild-type of familial Parkinson's disease-linked PARK72009
Author(s)
Yanagida, T., Kitamura, Y., Yamane, K., Takahashi, K., Takata, K., Yanagisawa, D., Yasui, H., Taniguchi, T., Taira, T., Honda, T. and Ariga, H.
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Journal Title
J. Pharmacol. Sci
Volume: 109
Pages: 463-468
Related Report
Peer Reviewed
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[Journal Article] Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury2009
Author(s)
Yanagida, T., Tsushima, J., Kitamura, Y., Yanagisawa, D., Takata, K., Shibaike, T., Yamamoto, A., Taniguchi, T., Yasui, H., Taira, T., Morikawa, S., Inubushi, T., Tooyama, I. and Ariga, H.
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Journal Title
Oxidative Medicine & Cellular Longevity
Volume: 1
Pages: 36-42
NAID
Related Report
Peer Reviewed
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[Presentation] Identification of MeCP2-targetsynaptic molecules associated with pathogenesis of Rett syndrome2010
Author(s)
Kunio Miyake, Takae Hirasawa, Masaki soutome, Masayuki, Itoh, Yu-ichi Goto, Kazushi Endoh, Shinichi Kudou, Sana Yokoi, Takahiro Taira, Johji Inazawa, Takeo Kubota
Organizer
第33回日本分子生物学会年会第83回日本生化学会大会合同会
Place of Presentation
神戸市
Year and Date
2010-12-08
Related Report
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