Elucidation of the molecular basis attributed to onset of abnormal retinal hemodynamics and strategy of novel prevention drugs for retinopathy
| Project/Area Number |
21590102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
ISHII Kunio 北里大学, 薬学部, 教授 (90137993)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAHARA Tsutomu 北里大学, 薬学部, 准教授 (10296519)
MORI Asami 北里大学, 薬学部, 助教 (80453504)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 薬理学 / 微小循環 / 糖尿病 / 血管生物学 / 網膜 |
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| Research Abstract |
This study demonstrated that retinal vasodilator responses mediated through the mechanism involving activation of the large-conductance Ca^<2+>-activated K^+(BK_<Ca>) channel was diminished at the early stage of diabetes in rats. Furthermore, it was suggested that the oxydative stress was increased in retinal blood vessels of diabetes rats. Thus, impairment of BK_<Ca> channel function and increased oxidative stress may contribute to abnormal retinal hemodynamics in diabetes and consequently play an important role in the pathogenesis of diabetic retinopathy. In conclusion, drugs that improve retinal circulation and possess antioxidative effect are considered to be novel candidates for prevention of retinopathy.
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Report
(4 results)
Research Products
(39 results)
