| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
This study demonstrated that retinal vasodilator responses mediated through the mechanism involving activation of the large-conductance Ca^<2+>-activated K^+(BK_<Ca>) channel was diminished at the early stage of diabetes in rats. Furthermore, it was suggested that the oxydative stress was increased in retinal blood vessels of diabetes rats. Thus, impairment of BK_<Ca> channel function and increased oxidative stress may contribute to abnormal retinal hemodynamics in diabetes and consequently play an important role in the pathogenesis of diabetic retinopathy. In conclusion, drugs that improve retinal circulation and possess antioxidative effect are considered to be novel candidates for prevention of retinopathy.
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