| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
On brain insults, such as stroke, subarachnoid hemorrhage and head trauma, brain edema occurs. Although brain edema is a mortal pathology, effective drug treatments for it have not been established. To generate a novel drug against brain edema, mechanisms underlying brain edema formation were examined bbyb using animal models. We found that endothelins, (ETs), a vasoconstricting peptides, are potent inducers of various edema factors in rat brain and in cultured glial cells. These findings suggest that inhibition of ET receptors in glial cells on brain insults have beneficial actions to prevent brain edema frormation.
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