| Project/Area Number |
21590111
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Setsunan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURAMOTO Nobuyuki 摂南大学, 薬学部, 准教授 (60324092)
YONEYAMA Masanori 摂南大学, 薬学部, 講師 (00411710)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 海馬 / 神経障害 / 神経新生 / 神経系幹細胞 / ミクログリア / 活性酸素 / 活性窒素 / 神経細胞死 / トリメチルスズ / NF-kappaB / TNF-alfa / ミノサイクリン / 神経細胞新生 / エダラボン / 神経系前駆細胞 / ニューロスフェアー / BrdU取り込み / 脳室下帯 |
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| Research Abstract |
In adult brain, neural stem cells is known to proliferate and differentiate with regulation by endogenous and exogenous factors. Developing model animals for neuronal degeneration and regeneration, we found trimethyltintreated mice as a model. Using the model, we evaluated that NMDA signals, reactive oxygen and nitrogen species, inflammatory cytokines, and microglia contribute to neurogenesis following neuronal loss in the hippocampal dentate gyrus.
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