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Development of a cancer treatment technique using intracellular collapsing liposomes directed to cancer with double safety systems

Research Project

Project/Area Number 21590115
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Drug development chemistry
Research InstitutionThe University of Tokushima

Principal Investigator

NAGAMUNE Hideaki  徳島大学, 大学院・ソシオテクノサイエンス研究部, 教授 (40189163)

Co-Investigator(Kenkyū-buntansha) TOMOYASU Toshifumi  徳島大学, 大学院・ソシオテクノサイエンス研究部, 准教授 (20323404)
TABATA Atsushi  徳島大学, 大学院・ソシオテクノサイエンス研究部, 助教 (10432767)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords医薬分子設計 / 癌治療法 / DDS / 細菌毒素
Research Abstract

We aimed to develop a novel effective and safe technique for cancer treatment using bacterial toxins with dual safety systems. First, a targeting toxin with safety system and the variable targeting ability was developed. It was confirmed that the liposomes enclosed anticancer drug prepared by using the targeting toxin and anti-carcinoembryonic antigen(CEA) IgG could specifically target to CEA-positive cancer cells and were effective to prolong life of mice inoculated with CEA-positive cancer cells. The second cytotoxic effector toxin with safety system was also produced, so the development of a novel technique for the target-variable cancer treatment using both toxins with safety systems came in sight.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (9 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Journal Article] Investigation of a Bacterial Pore-forming Chimera Toxin for Application as a Novel Drug-delivery System Tool2012

    • Author(s)
      A. Tababa, Y. Ohkubo, E. Sakakura, T. Tomoyasu, K. Ohkura, H. Nagamune
    • Journal Title

      Anticancer Research

      Volume: Vol.32, No.6 Pages: 2323-2330

    • URL

      http://ar.iiarjournals.org/content/32/6/2323.full.pdf

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 膜孔形成性キメラ毒素の新規DDSツールとしての応用性に関する検討2011

    • Author(s)
      田端厚之ら
    • Organizer
      第15回バイオ治療法研究会学術集会
    • Place of Presentation
      福岡大学病院メディカルホール
    • Year and Date
      2011-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞標的化キメラ毒素を用いたDDSツールの開発と応用2011

    • Author(s)
      長宗秀明ら
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2011-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞標的化キメラ毒素を用いたDDSツールの開発と応用2011

    • Author(s)
      長宗秀明
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 汎用性の標的可変型DDSツールの開発2011

    • Author(s)
      長宗秀明ら
    • Organizer
      神戸学院大学LSC研究会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2011-03-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 細菌由来膜孔形成性機能分子を用いたDDSツールの会子設計とその機能評価2011

    • Author(s)
      田端厚之, ら
    • Organizer
      神戸学院大学LSC研究会「高齢化社会における加齢性疾患の予防・治療薬と機能性食品の開発」
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2011-03-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 汎用性の標的可変型DDSツールの開発2011

    • Author(s)
      長宗秀明, ら
    • Organizer
      神戸学院大学LSC研究会「高齢化社会におけ加齢型疾患め予防・治療薬と機能性食品の開発」
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2011-03-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細菌由来膜孔形成性機能分子を用いたDDSツールの分子設計とその機能評価2011

    • Author(s)
      田端厚之ら
    • Organizer
      神戸学院大学LSC研究会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2011-03-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 異なる受容体を認識するコレステロール依存性細胞溶解毒素の細胞結合特性2010

    • Author(s)
      長宗秀明, ら
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis on cell membrane recognition of bacterial toxins for DDS tools2010

    • Author(s)
      Hideaki Nagamune, et al.
    • Organizer
      Spring Meeting of Cooperative Research Center of Life Sciences, Kobe Gakuin University
    • Place of Presentation
      Kobe Gakuin University
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] コレステロール依存性細胞溶解毒素の変異体及びそのDDSへの利用2012

    • Inventor(s)
      長宗秀明、友安俊文、田端厚之
    • Industrial Property Rights Holder
      国立大学法人徳島大学
    • Filing Date
      2012-03-09
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] コレステロール依存性細胞溶解毒素の変異体及びそのDDSへの利用2012

    • Inventor(s)
      長宗秀明, 友安俊文, 田端厚之
    • Industrial Property Rights Holder
      徳島大学
    • Filing Date
      2012-03-09
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] コレステロール依存性細胞溶解毒素の変異体及びそのDDSへの利用2011

    • Inventor(s)
      長宗秀明、友安俊文、田端厚之
    • Industrial Property Rights Holder
      国立大学法人徳島大学
    • Industrial Property Number
      2011-051295
    • Filing Date
      2011-03-09
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] コレステロール依存性細胞溶解毒素の変異体及びそのDDSへの利用2011

    • Inventor(s)
      長宗秀明, 友安俊文, 田端厚之
    • Industrial Property Rights Holder
      国立大学法人徳島大学
    • Filing Date
      2011-03-09
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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