| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Drug design, molecular docking, molecular dynamics simulation and synthesis of octacationic porphyrins bearing pyridiniums at their meso and terminal positions were carried out, because these were expected to interact with telomere quadruplex DNA more electrostatically and tightly than did tetracationic porphyrins. In addition, crystallization of the complex of telomere quadruplex DNA with the octacationic porphyrins was attempted.
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