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Development of new anti-Alzheimer

Research Project

Project/Area Number 21590120
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Drug development chemistry
Research InstitutionChiba Institute of Science

Principal Investigator

HAMANA Hiroshi  千葉科学大学, 薬学部, 教授 (00383472)

Co-Investigator(Kenkyū-buntansha) MIMORI Eisuke  千葉科学大学, 薬学部, 助手 (70433688)
飯田 博一  千葉科学大学, 薬学部, 講師 (10335797)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsアルツハイマー病 / パーキンソン病 / メマンチン / アダマンタン / NMDA受容体 / アミノアダマンタン / 臭素化 / 光学活性なアダマンタン / MK-801 / 構造活性相関 / プロモアダマンタン
Research Abstract

In 2011, three new chemicals were applicable for treatment of Alzheimer's disease. Among them, interested in chemical structure and biological activity of memantine, we developed the synthetic methodology of 1-amino-3, 5-dialkyladamantanes. In the synthesis of these compounds, alkylation of bridgehead carbon is the key reaction. Optical resolution of 1-amino-3-methl-5-propyladamantane is under investigation.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2012 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (17 results)

  • [Journal Article] Protective effects of 4-Phenylbutyrate derivatives on the neuronal cell death and endoplasmic reticulum stress2012

    • Author(s)
      Seisuke Mimori, Yasunobu Okuma, Masayuki Kaneko, Koichi Kawada, Toru Hosoi, Koichiro Ozawa, Yasuyuki Nomura, Hiroshi Hamana
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 35(1) Pages: 84-90

    • NAID

      130001872347

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain2011

    • Author(s)
      Kawada K、Kaneko M、Nomura Y、Mimori S、Hamana H、Ogita K、Murayama T、Fujino H、 Okuma Y
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 117 Issue: 3 Pages: 208-212

    • DOI

      10.1254/jphs.11120SC

    • NAID

      10030453464

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] ハロボランをLewis酸とするニトリルの細見-櫻井反応及びホモアリルアミン合成の展開2012

    • Author(s)
      高山倫一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 神経変性疾患治療薬を目指した低分子化合物の合成と評価(2)2012

    • Author(s)
      三森盛亮
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ジアルキルボリルトリフレートを用いたニトリルの向山-type反応2012

    • Author(s)
      川島裕也
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Synthesis and Evaluation of Small Molecules for Therapeutic Agents of Neurodegenerative Disease2011

    • Author(s)
      三森盛亮
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium(AIMECS11)
    • Place of Presentation
      東京
    • Year and Date
      2011-12-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Synthesis and Evaluation of Small Molecules for Therapeutic Agents of Neurodegenerative Disease2011

    • Author(s)
      三森盛亮、浜名洋, 他
    • Organizer
      8^<th> AFMC International Medicinal Chemistry Symposium (AIMECS11)
    • Place of Presentation
      東京
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] A New Synthetic Method of Pyridone and Pyridine Using Intramolecular Hosomi-Sakurai Reaction of Nitriles2011

    • Author(s)
      川島裕也
    • Organizer
      23^<rd> International Congress on Heterocyclic Chemistry(ICHC2011)
    • Place of Presentation
      グラスゴー
    • Year and Date
      2011-08-02
    • Related Report
      2011 Final Research Report
  • [Presentation] A New Synthetic Method of Pyridone and Pyridine Using Intramolecular Hosomi-Sakurai Reaction of Nitriles2011

    • Author(s)
      川島裕也、浜名洋, 他
    • Organizer
      23^<rd> International Congress on Heterocyclic Chemistry (ICHC2011)
    • Place of Presentation
      グラスゴー
    • Year and Date
      2011-08-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] ニトリルの櫻井-細見反応を利用した新規ホモアリルアミン合成2011

    • Author(s)
      高山倫一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経変性疾患治療薬を目指した低分子化合物の合成と評価2011

    • Author(s)
      三森盛亮
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2011 Final Research Report
  • [Presentation] ニトリルに対する向山交差アルドール反応の新展開2011

    • Author(s)
      川島裕也
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] ナフタレン誘導体の合成とケミカルシャペロン活性2011

    • Author(s)
      三森盛亮、浜名洋, 他
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] アダマンタンダイマーの合成と細胞増殖への影響2011

    • Author(s)
      荒野直紀、浜名洋, 他
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経変性疾患治療薬を目指したナフタレン誘導体の合成と評価2010

    • Author(s)
      三森盛亮
    • Organizer
      第29回メディシナルケミストリーシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 4-フェニル酪酸誘導体の合成と構造活性相関2010

    • Author(s)
      三森盛亮、浜名洋, 他
    • Organizer
      第29回メディシナルケミストリーシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] ナフタレン誘導体の合成とケミカルシャペロン活性2010

    • Author(s)
      三森盛亮
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] アダマンタンダイマーの合成と細胞増殖への影響2010

    • Author(s)
      荒野直紀
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 4-フェニル酪酸誘導体の合成と構造活性相関2009

    • Author(s)
      三森盛亮
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-11-25
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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