| Project/Area Number |
21590120
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Chiba Institute of Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIMORI Eisuke 千葉科学大学, 薬学部, 助手 (70433688)
飯田 博一 千葉科学大学, 薬学部, 講師 (10335797)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アルツハイマー病 / パーキンソン病 / メマンチン / アダマンタン / NMDA受容体 / アミノアダマンタン / 臭素化 / 光学活性なアダマンタン / MK-801 / 構造活性相関 / プロモアダマンタン |
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| Research Abstract |
In 2011, three new chemicals were applicable for treatment of Alzheimer's disease. Among them, interested in chemical structure and biological activity of memantine, we developed the synthetic methodology of 1-amino-3, 5-dialkyladamantanes. In the synthesis of these compounds, alkylation of bridgehead carbon is the key reaction. Optical resolution of 1-amino-3-methl-5-propyladamantane is under investigation.
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