| Project/Area Number |
21590122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
GOUDA Hiroaki 北里大学, 薬学部, 准教授 (60276160)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAOTSU Noriyuki 北里大学, 薬学部, 講師 (60230322)
NAKAGOME Izumi 北里大学, 薬学部, 助教 (30237242)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 抗ガン剤 / イン・シリコ分子設計 / 蛋白質-蛋白質相互作用 / 抗癌剤 / ドラッグデザイン / タンパク質間相互作用 / 医薬分子設計 / イン・シリコ創薬 / 蛋白-蛋白相互作用 / 抗ガン剤開発 |
|---|
| Research Abstract |
The interaction between adapter protein CRK and guanine-nucleotide exchange protein C3G is an attractive target for the development of novel anticarcinogenic agent. Therefore, we explored inhibitors against this protein-protein interaction using a variety of in silico drug discovery technique.
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