| Project/Area Number |
21590124
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Teikyo University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TABATA Hidetsugu 帝京大学, 薬学部, 助手 (80445634)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 軸不斉 / キラリティー / γ-セクレターゼ阻害薬 / ACAT阻害薬 / バソプレッシン受容体拮抗薬 / ジベンゾジアゼピノン / ベンゾラクタム / 1,5-ベンゾジアゼピノン / 窒素のキラリティー / インドメタシン |
|---|
| Research Abstract |
The active conformation of biologically active compounds(e. g.,(1) a γ secretase inhibitor, (2) new vasopressin V_1, V_2 receptor antagonists, and (3) new ACAT inhibitors) was elucidated, and the axial chirality originated from an aryl-amide moiety of the molecules was shown to play important role on exerting the activity.
|
