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Polymers with chemically bound bioactive molecules : Synthesis and application to slow drug-delivery

Research Project

Project/Area Number 21590127
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Drug development chemistry
Research InstitutionNihon University

Principal Investigator

WAKATSUKI Yasuo  日本大学, 文理学部, 教授 (20087513)

Co-Investigator(Kenkyū-buntansha) IIDA Takashi  日本大学, 文理学部, 教授 (60060125)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords医薬分子設計 / ポリマー / フィルム / ノルボルネン / 開環重合 / 付加重合 / ノルボルネン付加重合 / ゼロ価パラジウム触媒 / ビニルノルボルネン / 分子量制御 / 耐熱性フィルム / ROMPポリマー / 抗菌フィルム / 銀イオン / ピリジル基 / 大腸菌 / 枯草菌 / ステロイド / 徐放性医薬 / Grubbs触媒 / ビニリデン錯体 / ポリマーフィルム
Research Abstract

Slow drug-delivery is an important theme in therapeutic use of steroids and hormones. Some polymer materials have been employed as a matrix but mostly by means of simple physical mixing with drugs, which often leads to unreproducible release of the medicinal molecules. In this project, we have developed new methods to prepare suitable polymers with chemically bonded pendant of bioactive molecules or ions and aimed at creation of bioactive polymer films which are constantly valid for a long pe-riod of time under ambient conditions.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (7 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Addition poly-merization of norbornene, 5-vinyl-2-norbornene and 2-methoxycarbonyl-5-norbornene with a catalyst based on a palladium(0) precursor complex2012

    • Author(s)
      T. Saito, Y. Wakatsuki
    • Journal Title

      Polymer

      Volume: Vol.53 Pages: 308-315

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of 3-Sulfates of S-Acyl Glutathione Conjugated Bile Acids and their Biotransformation by a Rat Liver Cytosolic Fraction2012

    • Author(s)
      K. Mitamura, N. Hori, S. Mino, T. Iida, A. F. Hofmann, S. Ikegawa
    • Journal Title

      Chem. Phys. Lipids

      Volume: Vol.165 Pages: 261-269

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Addition polymerization of norbornene, 5-vinyl-2-norbornene and 2-methoxycarbonyl-5-norbornene with a catalyst based on a palladium(0) precursor complex2012

    • Author(s)
      斎藤竜也、若槻康雄
    • Journal Title

      Polymer

      Volume: 53 Issue: 2 Pages: 308-315

    • DOI

      10.1016/j.polymer.2011.12.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2011

    • Author(s)
      S. Takano, H. Tamegai, T. Ito, S. Oga-wa, T. Iida, Y. Wakatsuki
    • Journal Title

      React. Funct. Polm

      Volume: Vol.71 Pages: 195-203

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemical Syn-thesis of the(25R)-and(25S)-Epimers of 3α, 7α, 12α-Trihydroxy-5α-cholestan-27-oic Acid as well as Their Corresponding Glycine and Taurine Conjugates2011

    • Author(s)
      S. Ogawa, K. Mitamura, S. Ikegawa, M. D. Krasowski, L. R. Hagey, A. F. Hofmann, T. Iida
    • Journal Title

      Chem. Phys. Lipids

      Volume: Vol.164 Pages: 368-377

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ROMP-polymer-based antimicrobial films repeatedly chargeable with silver ions2011

    • Author(s)
      高野重永、為我井秀行、伊藤敏宏、小川祥二郎、飯田隆、若槻康雄
    • Journal Title

      React.Funct.Polym.

      Volume: 71 Pages: 195-203

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ring-opening me-tathesis polymerization of ster-oid-conjugated norbornenes and grad-ual release of estrone from a polymer film2010

    • Author(s)
      S. Ogawa, S. Takano, H. Fujimori, T. Iida, Y. Wakatsuki
    • Journal Title

      React. Funct. Polm

      Volume: Vol.70 Pages: 563-571

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxyfunctionalization of Unactivated C-H Bonds in Triterpenoids with tert-Butyl-hydroperoxide Catalyzed by Meso-5, 10, 15, 20-tetramesitylporphyrinate Osmium(II) Carbonyl Complex2010

    • Author(s)
      S. Ogawa, Y. Wakatsuki, M. Makino, Y. Fujimoto, K. Yasukawa, T. Kikuchi, M. Ukiya, T. Akihisa, T. Iida
    • Journal Title

      Chem. Phys. Lipids

      Volume: Vol.163 Pages: 165-171

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ring-opening metathesis polymerization of steroid-conjugated norbornenes and gradual release of estrone from a polymer film2010

    • Author(s)
      小川祥二郎、高野重永、藤森裕基、飯田隆、若槻康雄
    • Journal Title

      React.Funct.Polym.

      Volume: 70 Pages: 563-571

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxyfunctionalization of unactivated C-H bonds in triterpenoids with2010

    • Author(s)
      S.Ogawa, Y.Wakatsuki, T.IIda
    • Journal Title

      Chemistry and Physics of Lipids 163

      Pages: 165-171

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脂肪肝予防・治療薬としてのFXRリガンドの可能性について2011

    • Author(s)
      宮崎照雄, 本多彰, 池上正, 飯田隆, 松崎靖司
    • Organizer
      第33回胆汁酸研究会
    • Place of Presentation
      大阪ガーデンパレス
    • Related Report
      2011 Final Research Report
  • [Presentation] オリゴシロキサン含有ポリノルボルネン誘導体の合成とその物性2011

    • Author(s)
      手塚裕昭、若槻康雄
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学
    • Related Report
      2011 Final Research Report
  • [Presentation] Pd(0)錯体を用いたノルボルネンとビニルノルボルネンの付加共重合2011

    • Author(s)
      斎藤竜也、庭山和樹、酒井佑輔、若槻康雄
    • Organizer
      第91日本化学会春季年会
    • Place of Presentation
      神奈川大学
    • Related Report
      2011 Final Research Report
  • [Presentation] ピリジン-銀錯体を結合したROMPポリマーの合成と抗菌フィルムへの応用2010

    • Author(s)
      為我井秀行, 飯田隆, 若槻康雄
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      近畿大学
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 潜在的胆汁酸3α, 7α, 12α-Trihydroxy-5α-cholestan-26-oic acidエピマー体とその抱合体の化学合成2010

    • Author(s)
      小川祥二郎、飯田隆、岡田浩章、池川繁男、三田村邦子、A. F. Hofmann
    • Organizer
      第32回胆汁酸研究会
    • Place of Presentation
      東北大学
    • Related Report
      2011 Final Research Report
  • [Presentation] Addition Polymerization of Substituted Norbornenes Using Palla-dium(0) Complexes2010

    • Author(s)
      T. Saito, H. Fujimori, Y. Wakatsuki, H. Tetsuka
    • Organizer
      第57回有機金属化学討論会
    • Place of Presentation
      中央大学
    • Related Report
      2011 Final Research Report
  • [Presentation] ピリジン-銀錯体を結合したROMPポリマーの合成と抗菌フィルムへの応用2010

    • Author(s)
      小方聖太郎、伊藤敏宏、為我井秀行、小川祥二郎、飯田隆、若槻康雄
    • Organizer
      第90日本化学会春季年会
    • Place of Presentation
      近畿大学
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] ノルボルネン付加重合用パラジウム触媒並びにノルボルネン付加重合体及びその製造方法2011

    • Inventor(s)
      若槻康雄
    • Industrial Property Rights Holder
      学校法人日本大学
    • Industrial Property Number
      2011-036048
    • Filing Date
      2011-02-22
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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