Polymers with chemically bound bioactive molecules : Synthesis and application to slow drug-delivery
| Project/Area Number |
21590127
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IIDA Takashi 日本大学, 文理学部, 教授 (60060125)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 医薬分子設計 / ポリマー / フィルム / ノルボルネン / 開環重合 / 付加重合 / ノルボルネン付加重合 / ゼロ価パラジウム触媒 / ビニルノルボルネン / 分子量制御 / 耐熱性フィルム / ROMPポリマー / 抗菌フィルム / 銀イオン / ピリジル基 / 大腸菌 / 枯草菌 / ステロイド / 徐放性医薬 / Grubbs触媒 / ビニリデン錯体 / ポリマーフィルム |
|---|
| Research Abstract |
Slow drug-delivery is an important theme in therapeutic use of steroids and hormones. Some polymer materials have been employed as a matrix but mostly by means of simple physical mixing with drugs, which often leads to unreproducible release of the medicinal molecules. In this project, we have developed new methods to prepare suitable polymers with chemically bonded pendant of bioactive molecules or ions and aimed at creation of bioactive polymer films which are constantly valid for a long pe-riod of time under ambient conditions.
|
Report
(4 results)
Research Products
(18 results)
-
-
-
-
[Journal Article]2011
Author(s)
S. Takano, H. Tamegai, T. Ito, S. Oga-wa, T. Iida, Y. Wakatsuki
-
Journal Title
React. Funct. Polm
Volume: Vol.71
Pages: 195-203
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Oxyfunctionalization of Unactivated C-H Bonds in Triterpenoids with tert-Butyl-hydroperoxide Catalyzed by Meso-5, 10, 15, 20-tetramesitylporphyrinate Osmium(II) Carbonyl Complex2010
Author(s)
S. Ogawa, Y. Wakatsuki, M. Makino, Y. Fujimoto, K. Yasukawa, T. Kikuchi, M. Ukiya, T. Akihisa, T. Iida
-
Journal Title
Chem. Phys. Lipids
Volume: Vol.163
Pages: 165-171
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
