| Project/Area Number |
21590129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokyo (2011)
Kyoto Pharmaceutical University (2009-2010) |
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Principal Investigator |
SAITO Kazuki 東京大学, 大学院・新領域創成科学研究科, 特任研究員 (10192585)
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| Co-Investigator(Renkei-kenkyūsha) |
KISO Yoshiaki 長浜バイオ大学, バイオサイエンス学部, 客員教授 (40089107)
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| Research Collaborator |
MIZUGUCHI Takaaki 京都薬科大学, 薬学部, 大学院生
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 医薬分子設計 / レセプター創薬 / 二量化阻害 / ループ構造模倣環状ペプチド / EGFレセプター / 二量化阻害環状ペプチド / 親和性増強 / レトロインバーソ / コンビナトリアル合成 / 表面プラズモン共鳴 / キャピラリー電気泳動 / ジスルフィド架橋形成 / 二量化アーム模倣ペプチド / 自己リン酸化阻害 / 環状ペプチド |
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| Research Abstract |
Aiming at development of new EGF-receptor-targeting anti-cancer drugs, a peptide that inhibits the receptor dimerization has been designed, based on the crystal structure of the receptor ectodomains dimerized by EGF. A cyclic peptide, which mimics the loop structure of a
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