Probing the catalytic mechnism of ribozymes and breast cancer inhibitory effects based on imidazole C-nucleosides
| Project/Area Number |
21590130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MASANORI Takaoka 大阪薬科大学, 薬学部, 教授 (50140231)
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | イミダゾール / C-リボヌクレオシド / リボザイム / テトラゾール / ヒスタミンH3受容体 / アンタゴニスト / 乳癌 / ホスホロアミダイト / DNA / ヒスタミンH3 / 増殖抑制 / 反応機構 / マイクロウエーブ / 抗癌剤 / 白金錯体 / Ｈ３アンタゴニスト / ホロアミダイド / chemo-genetic method / 乳癌増殖阻害 / 17β-HSD / H_3アンタゴニスト / 白金(II)二核錯体 / RNA / ホスホロアミダイド / エストラジオール / ハイブリッド |
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| Research Abstract |
Tetrazole C-nucleoside phosphoramidites,efficient synthesis of tetrazoles,and imidazole base pairing effects on DNA,and synthesis of H3R antagonist (OUP-186) as anti-cancer agents were carried out.
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Report
(6 results)
Research Products
(97 results)
