Elucidation of mechanism on exacerbation of allergy by ingestion of trichloroethylene as a groundwater pollutant from drinking water
| Project/Area Number |
21590134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | トリクロロエチレン / 即時型アレルギー / アレルギー反応増強 / サイトカイン分泌 / T細胞増殖 / T細胞受容体 / CD8+T細胞 / T細胞 / CD8陽性細胞 / T細胞増殖亢進 / IL-2 / IL-4 / TNF-α / IFN-γ |
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| Research Abstract |
The author had found that ingestion of trichloroethylene(TCE) as a groundwater pollutant from drinking water exacerbated allergy in rats and mice experiments. In this study, the mechanisms have been elucidated with mouse in vivo and in vitro experiments, as follows.(1) TCE ingestion from drinking water enhanced antigen-specific T cell proliferation, and the enhancement was associated with increase of IL-3 secretion.(2) Increase of TNF-a secretion from T cell directly enhanced inflammation.(3) TCE exposure enhanced T cell proliferation, and TCE acts as a potential T cell stimulator to accelerate the T cell receptor(TCR)-CD3-mediated signaling pathway.
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Report
(4 results)
Research Products
(19 results)
