Molecular basis for intracellular zinc-responsive system and its application as the imaging sensor for heavy metals.
| Project/Area Number |
21590136
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental pharmacy
|
|---|
| Research Institution | Teikyo University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOIZUMI Shinji (独)安衛研, 研究企画調整部, 特任研究員 (80183325)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SHIMOYAMA Tae 帝京大学, 薬学部, 助教 (30433882)
OSADA Yoichi 帝京大学, 薬学部, 助教 (50545572)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 環境衛生学 / 亜鉛センサー / 亜鉛 / 転写因子 / 環境 / 衛生 |
|---|
| Research Abstract |
MTF-1 is a heavy-metal dependent transcription factor and the molecular basis of its response to heavy metals is thought to be useful for developing a novel sensor system for heavy metals. Using various deletion and point mutatnts of MTF-1, we found that the Zn-finger domain does not solely function as the DNA-binding domain, but it plays multifunctional roles for the responses of MTF-1 against heavy metals. This indicates that the Zn-finger domain of MTF-1 is a useful module to design a novel artificial molecule for sensing heavy metals.
|
Report
(4 results)
Research Products
(9 results)
