| Project/Area Number |
21590137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMASAKI Masahiro 星薬科大学, 薬学部, 准教授 (80328921)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | メタボリックシンドローム / ケトン体 / 脂肪細胞 / アセトアセチルCoA合成酵素 / 肥満 / AMPK / レプチン / 脂肪酸 |
|---|
| Research Abstract |
In order to clarify the role of ketone body-utilization on metabolic disorders, we investigated obesity-induced alterations in the gene expression levels of the newly ketone body-utilizing enzyme, acetoacetyl-CoA synthetase(AACS), in peripheral tissues or central nerve system. As a result, we found that AACS gene expression was affected by treatment with free fatty acid and isoproterenol in white adipocytes. Moreover, we found the possibility that leptin up-regulates ketone body-utilization in neuro-cells and myocytes via activating the AACS transcription.
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