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Development of an accurate analysis method of the intestinal bacterial flora, and detect the causative bacteria of ulcerative colitis, search its effective antibiotics.

Research Project

Project/Area Number 21590138
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental pharmacy
Research InstitutionAichi Gakuin University

Principal Investigator

KAWAMURA Yoshiaki  愛知学院大学, 薬学部, 教授 (80262757)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords微生物 / 感染症学 / 感染症 / 細菌叢 / 潰瘍性大腸炎
Research Abstract

Total DNA extracted from the fecal sample of UC model mouse and the healthy mouse were analyzed by DGGE method. As a result, we could find some new bands which were specific for UC model mouse. Furthermore we could obtain 15,000~40,000 sequence read from each specimen by pyrosequencer(Roche 454-FLX-Titanium), and find the certain bacteria whose population was increasing in UC model mouse.
After orally given Clostridium sp. ID4 strain-one representative organism which was identified from UC model mouse-, we could find the inflammatory image in the lower portion of the large intestine.
From these data, we concluded that the certain bacteria founding this study were not a little related with the UC onset.

Report

(5 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Products Report
  • Research Products

    (10 results)

All 2018 2017 2016 2015 2012 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (9 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Paraclostridium bifermentans exacerbates pathosis in a mouse model of ulcerative colitis2018

    • Author(s)
      Kutsuna R, Tomida J, Morita Y, Kawamura Y.
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 5 Pages: e0197668-e0197668

    • DOI

      10.1371/journal.pone.0197668

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Presentation] 同属菌種間にみられたマウスDSS感受性の違い2017

    • Author(s)
      久綱僚、富田純子、森田雄二、河村好章
    • Organizer
      第63回日本細菌学会中部支部総会
    • Related Report
      Products Report
  • [Presentation] Acertain Clostridium sp. might be affected UC model mouse status adversely.2017

    • Author(s)
      Kutsuna R, Tomida J, Morita Y, Kawamura Y.
    • Organizer
      International Union of Microbiological Societies 2017, Singapore
    • Related Report
      Products Report
    • Int'l Joint Research
  • [Presentation] 特定のClostridium sp.はUCモデルマウスにおける病態悪化因子となり得る2017

    • Author(s)
      久綱 僚, 富田 純子, 森田 雄二, 河村 好章
    • Organizer
      日本薬学会第137年会
    • Related Report
      Products Report
  • [Presentation] 潰瘍性大腸炎モデルマウス病態増悪因子としてのClostridium sp.ID42016

    • Author(s)
      久綱僚、富田純子、森田雄二、河村好章
    • Organizer
      第53回日本細菌学会中部支部総会
    • Related Report
      Products Report
  • [Presentation] Clostridium sp.ID4のDSS誘発性大腸炎モデルマウス病態への関与2016

    • Author(s)
      久綱僚、富田純子、森田雄二、河村好章
    • Organizer
      第28回微生物シンポジウム
    • Related Report
      Products Report
  • [Presentation] 腸炎モデルマウス腸内細菌叢に優位に存在するClostridium sp.ID4による炎症誘発機構の検討2016

    • Author(s)
      富田純子, 中島健一, 鈴木裕可, 森田雄二, 波多野紀行, 井上誠, 河村好章
    • Organizer
      日本薬学会 第136年会
    • Related Report
      Products Report
  • [Presentation] DGGE(変性剤濃度勾配ゲル電気泳動)法を用いたUCモデルマウス腸内細菌叢の構造解析2015

    • Author(s)
      久綱僚、冨田純子、森田雄二、河村好章
    • Organizer
      第61回日本薬学会東海支部総会・大会
    • Related Report
      Products Report
  • [Presentation] メタゲノム法による潰瘍性大腸炎モデルマウスの糞便細菌叢の精査解析2012

    • Author(s)
      河村好章、神谷保吉、富田純子、森田雄二、森裕志
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 細菌の分類同定に使われる方法論とヒトの消化管に生息する細菌の分類命名に関する情報2009

    • Author(s)
      河村好章
    • Organizer
      第12回に本臨床腸内微生物学会総会
    • Place of Presentation
      岐阜
    • Year and Date
      2009-09-05
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2019-02-27  

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