| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Total DNA extracted from the fecal sample of UC model mouse and the healthy mouse were analyzed by DGGE method. As a result, we could find some new bands which were specific for UC model mouse. Furthermore we could obtain 15,000～40,000 sequence read from each specimen by pyrosequencer(Roche 454-FLX-Titanium), and find the certain bacteria whose population was increasing in UC model mouse.
After orally given Clostridium sp. ID4 strain-one representative organism which was identified from UC model mouse-, we could find the inflammatory image in the lower portion of the large intestine.
From these data, we concluded that the certain bacteria founding this study were not a little related with the UC onset.
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