The inhibitory effect of aryl hydrocarbon receptor on spermatogenesis in vivo

Research Project

Project/Area Number	21590140
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Environmental pharmacy
Research Institution	Doshisha Women's College of Liberal Arts
Principal Investigator	KIZU Ryoichi 同志社女子大学, 薬学部, 教授 (80143915)
Co-Investigator(Kenkyū-buntansha)	SANADA Noriko 同志社女子大学, 薬学部, 助教 (60411089) GOTOH Yuka 同志社女子大学, 薬学部, 助手 (90509259)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	内分泌撹乱物質 / アリル炭化水素受容体 / 多環芳香族炭化水素 / 精子産生機能 / 内分泌撹乱作用物質
Research Abstract	In this study, we investigated the mechanism for the inhibitory effect of AhR agonist(BaP) on spermatogenesis in vivo. BaP showed high AhR agonist activity and weak inhibitory effect on spermatogenesis in vivo analysis. The inhibitory effect of BaP on spermatogenesis was abolished by co-treatment with an AhR antagonist, a-naphthoflavone. These results suggest that AhR is involved in the inhibition of spermatogenesis by BaP.

Report

(4 results)