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Molecular mechanism of zinc-induced neurotoxicity : involvement of Ca and ER stress

Research Project

Project/Area Number 21590145
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental pharmacy
Research InstitutionKyushu University of Health and Welfare

Principal Investigator

KAWAHARA Masahiro  九州保健福祉大学, 薬学部, 教授 (40224828)

Co-Investigator(Kenkyū-buntansha) SADAKANE Yutaka  鈴鹿医療科学大学, 薬学部, 教授 (60293304)
KOYAMA Hironari  九州保健福祉大学, 薬学部, 助手 (70567718)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords中毒学 / 無機金属毒性 / 亜鉛 / カルシウム / アポトーシス / カルノシン / プリオン / コンフォメーション / 銅 / 小胞体ストレス / アルツハイマー病 / プリオン病 / 脳血管性認知症 / イメージング
Research Abstract

Zinc(Zn) is neurotoxic and causes neurodegeneration following transient global ischemia and plays a crucial role in the pathogenesis of vascular-type dementia. We investigated the molecular mechanisms of Zn-induced neurotoxicity in vitro. The analysis of upregulated genes during Zn-induced neuronal death revealed that the significance of ER stress. These new results indicate that the disruption of Ca2+homeostasis and ER stress in the molecular mechanism of Zn-induced neurotoxicity, and are useful for the search for protective substances for vasucular dementia.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (74 results)

All 2012 2011 2010 2009

All Journal Article (27 results) (of which Peer Reviewed: 18 results) Presentation (39 results) Book (7 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Zinc neurotoxicity and the pathogenesis of vascular-type dementia : Involvement of calcium dyshomeostasis and carnosine2012

    • Author(s)
      Koyama H, Konoha K, Sadakane Y, Ohkawara S, and Kawahara M
    • Journal Title

      J. Clin Toxicol

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 亜鉛と認知症:脳の中のヤヌス2012

    • Author(s)
      川原正博
    • Journal Title

      ファルマシア

      Volume: 48 Pages: 216-220

    • NAID

      110009901048

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 神経疾患と微量金属2012

    • Author(s)
      川原正博、小山裕也、大河原晋
    • Journal Title

      金属

      Volume: 82 Pages: 19-27

    • Related Report
      2011 Final Research Report
  • [Journal Article] Zinc neurotoxicity and the pathogenesis of vascular-type dementia : Involvement of calcium dyshomeostasis and carnosine2012

    • Author(s)
      Koyama H, Konoha K, Sadakane Y, Ohkawara S, Kawahara M
    • Journal Title

      J.Clin Toxicol.

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane incorporation, channel formation, and disruption of calcium homeostasis by Alzheimer's s-amyloid protein2011

    • Author(s)
      Kawahara M., Ohtsuka I., Yokoyama S., Kato-Negishi M. and Sadakane Y
    • Journal Title

      Int. J. Alzheimer Dis.

      Pages: 304583-304583

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-1262011

    • Author(s)
      Kawahara M, Koyama H., Nagata T., Sadakane Y.
    • Journal Title

      Metallomics

      Volume: 3 Pages: 726-734

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アミロイド形成蛋白の高次構造変化と神経毒性に及ぼす金属の影響2011

    • Author(s)
      川原正博、小山裕也、定金豊
    • Journal Title

      Biomed. Res. Trace Elements

      Volume: 22 Pages: 7-14

    • NAID

      10028117958

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Link between aluminum and the pathogenesis of Alzheimer's disease : the integration of the aluminum and amyloid cascade hypotheses2011

    • Author(s)
      Kawahara M. and Kato-Negishi M.
    • Journal Title

      Int. J. Alzheimer Dis.

      Pages: 276393-276393

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] アミロイド形成蛋白の高次構造変化と神経毒性に及ぼす金属の影響2011

    • Author(s)
      川原正博、小山裕也、定金豊
    • Journal Title

      Biomed.Res.Trace Elements

      Volume: 28 Pages: 49-53

    • NAID

      10028117958

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane incorporation, channel formation, and disruption of calcium homeostasis by Alzheimer's β-amyloid protein2011

    • Author(s)
      Kawahara M., Ohtsuka I., Yokoyama S., Kato-Negishi M., Sadakane Y.
    • Journal Title

      Int.J.Alzheimer Dis.

      Volume: 2011 Pages: 304583-304583

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Link between aluminum and the pathogenesis of Alzheimer's disease : the integration of the aluminum and amyloid cascade hypotheses2011

    • Author(s)
      Kawahara M., Kato-Negishi M.
    • Journal Title

      Int.J.Alzheimer Dis.

      Volume: 2011 Pages: 276393-276393

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of calcium dyshomeostasis via amyloid channels in the pathogenesis of Alzheimer's disease2010

    • Author(s)
      Kawahara M
    • Journal Title

      Current Pharmaceutical Design

      Volume: 16 Pages: 2779-2789

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of UV-B irradiation on the stability of amino acids and peptides2010

    • Author(s)
      Sadakane Y, Fukuhara T, Kawahara M, Nakagomi K
    • Journal Title

      J. KUHW

      Volume: 11 Pages: 147-152

    • NAID

      110007577967

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantification of structural alterations of L-Asp and L-Asn residues in peptides related to neuronal disease by reversed-phase HPLC2010

    • Author(s)
      Sadakane Y, Konoha K., Kawahara M., Nakagomi K.
    • Journal Title

      Chem. & Biodivers

      Volume: 7 Pages: 1371-1379

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ligand structure for photoaffinity labeling of carbohydrate-binding protein2010

    • Author(s)
      Sadakane Y, Otsuka I, Konoha K, Koyama H, Kawahara M, Hatanaka Y
    • Journal Title

      Photomedicine and Photobiology

      Volume: 31 Pages: 9-10

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantification of structural alterations of L-Asp and L-Asn residues in peptides related to neuronal disease by reversed-phase HPLC2010

    • Author(s)
      Sadakane Y, Konoha K., Kawahara M., Nakagomi K.
    • Journal Title

      Chem.& Biodivers

      Volume: 7 Pages: 1371-1379

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of UV-B irradiation on the stability of amino acids and peptides.2010

    • Author(s)
      Sadakane Y, Fukuhara T, Kawahara M, Nakagomi K
    • Journal Title

      J.KUHW

      Volume: 11 Pages: 147-152

    • NAID

      110007577967

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Quantification of structural alterations of L-Asp and L-Asn residues in peptides related to neuronal disease by reversed-phase HPLC2010

    • Author(s)
      Sadakane Y, Konoha K., Kawahara M., Nakagomi K
    • Journal Title

      Chem. & Biodivers (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of UV-B irradiation on the stability of amino acids and peptides.2010

    • Author(s)
      Sadakane Y, Fukuhara T, Kawahara M, Nakagomi K
    • Journal Title

      J.KUHW 11

      Pages: 147-152

    • NAID

      110007577967

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Ligand structure for photoaffinity labeling of carbohydrate-binding protein.2010

    • Author(s)
      Sadakane Y, Otsuka I, Konoha K, Koyama H, Kawahara M, Hatanaka Y
    • Journal Title

      Photomedicine and Photobiology 31(In press)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Analysis of structural alternation of L-Asp and L-Asn residures in the peptides related to neuronal conformation disease2010

    • Author(s)
      Sadakane Y., Konoha K., Kawahara M
    • Journal Title

      KURRI-KR 148

      Pages: 1-5

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Preparation of recombinant Asp-isomerized crystalline and analysis of the effects of Asp alternation on protein function and structure using radiation.2010

    • Author(s)
      Sadakane Y., Fujii N
    • Journal Title

      KURRI Prog. Rep 2008

      Pages: 6-5

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      Kawahara M
    • Journal Title

      Metals and Neurodegeneration (Editor : Shile Huang)(Research Signpost)

      Pages: 15-56

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      Kawahara M, Konoha K, Nagata T, Sadakane Y
    • Journal Title

      Frontiers in CNS Drug Discovery(Bentham Science Publishers)

      Pages: 21-30

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Analysis of structural alternation of L-Asp and L-Asn residures in the peptides related to neuronal conformation disease2009

    • Author(s)
      Sadakane Y., Konoha K., Kawahara M.
    • Journal Title

      KURRI-KR

      Volume: 148 Pages: 1-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein2009

    • Author(s)
      Kawahara M. Negishi-Kato M, Sadakane Y.
    • Journal Title

      Expert Rev Neurother

      Volume: 9 Pages: 681-93

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein.2009

    • Author(s)
      Kawahara M., Negishi-Kato M, Sadakane Y
    • Journal Title

      Expert Rev Neurother 9

      Pages: 681-693

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] アルツハイマーβペプチドのN末側アミノ酸の構造的変化と線維化への影響2012

    • Author(s)
      定金豊,小山裕也,川原正博
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] PrP106-126の高次構造変化に重要な配列2012

    • Author(s)
      小山裕也,坂口哲陛,大河原晋,定金豊,川原正博
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] アルミニウムの神経毒性と神経疾患との関連2011

    • Author(s)
      川原正博、小山裕也
    • Organizer
      第22回日本微量元素学会シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 創薬シーズとしてのカルノシン2011

    • Author(s)
      川原正博
    • Organizer
      第4回薬学研究フォーラムin東京-九州からの情報発信による企業との共同研究マッチング-
    • Place of Presentation
      東京
    • Year and Date
      2011-01-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 創薬シーズとしてのカルノシン2011

    • Author(s)
      川原正博
    • Organizer
      第4回薬学研究フォーラムin東京-九州からの情報発信による企業との共同研究マッチング-」日本薬学会九州支部・九州薬科学研究教育連合主催
    • Place of Presentation
      東京
    • Year and Date
      2011-01-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] PrP断片ペプチドに対する亜鉛および銅の影響2011

    • Author(s)
      小山裕也,永田哲也,定金豊,川原正博
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Related Report
      2011 Final Research Report
  • [Presentation] コンフォメーション病に関与するペプチド中のアスanti-stressanti-oxidantanti-glycationanti-painanti-crosslink(Alzheimer, prion) pHbalanceCarnosineCH2CH2CNHOCHCCH2OHONNHH2Nパラギンおよびアスパラギン酸残基の構造変化と生理活性2011

    • Author(s)
      定金豊,小山裕也,川原正博
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of trace elements on the conformational changes of amyloidogenic proteins and their neurotoxicity2011

    • Author(s)
      Kawahara M.
    • Organizer
      5th International Conference on Metals and Genetics
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-1262011

    • Author(s)
      Koyama H, Okahara M, Sakaguchi T, Sadakane Y and Kawahara M
    • Organizer
      5th International Conference on Metals and Genetics
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Molecular Mechanism of zinc-induced neurotoxicity2011

    • Author(s)
      Kawahara M.
    • Organizer
      ISTERH(International Society for Trace Element Research in Humans)
    • Place of Presentation
      Antalya, Turkey
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular Mechanism of zinc-induced neurotoxicity2011

    • Author(s)
      Kawahara M
    • Organizer
      ISTERH (International Society for Trace Element Research in Humans)
    • Place of Presentation
      Antalya, Turkey
    • Related Report
      2011 Annual Research Report
  • [Presentation] 認知症から脳を保護するカルノシン2010

    • Author(s)
      川原正博
    • Organizer
      都市エリア産学官連携事業第9回浜辺のセミナー
    • Place of Presentation
      宮崎
    • Year and Date
      2010-10-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 認知症から脳を保護するカルノシン2010

    • Author(s)
      川原正博
    • Organizer
      都市エリア産学官連携事業 第9回浜辺のセミナー
    • Place of Presentation
      宮崎
    • Year and Date
      2010-10-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] プリオンペプチド断片(106-126)中のAsn残基の構造的変化と生理活性について2010

    • Author(s)
      定金豊,小山裕也,大塚功,木葉敬子,川原正博
    • Organizer
      第6回D-アミノ酸研究会学術講演会
    • Place of Presentation
      富山
    • Year and Date
      2010-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] カルノシンって何?-宮崎の食で認知症を防ぐ-2010

    • Author(s)
      川原正博
    • Organizer
      都市エリア産学官連携事業第8回浜辺のセミナー
    • Place of Presentation
      延岡
    • Year and Date
      2010-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] カルノシンって何?-宮崎の食で認知症を防ぐ2010

    • Author(s)
      川原正博
    • Organizer
      都市エリア産学官連携事業 第8回浜辺のセミナー
    • Place of Presentation
      延岡
    • Year and Date
      2010-08-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖鎖機能の効率的化未明を目指した光反応性糖鎖リガンドの製作2010

    • Author(s)
      定金豊,大塚功,川原正博,畑中保丸
    • Organizer
      第32回日本光医学・光生物学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-30
    • Related Report
      2011 Final Research Report
  • [Presentation] プリオンペプチド断片中のアスパラギン残基の構造的変化と生理活性2010

    • Author(s)
      定金豊
    • Organizer
      第130年会 日本薬学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] プリオン蛋白による培養細胞に対する亜鉛および銅の影響2010

    • Author(s)
      小山裕也
    • Organizer
      第130年会 日本薬学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Carnosine誘導体合成とGT1-7系における神経細胞保護効果2010

    • Author(s)
      鳥や尾篤
    • Organizer
      第130年会 日本薬学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 光アフィニティーラベル法による糖鎖機能解明を目指した新規分子ツールの創製2010

    • Author(s)
      大塚功
    • Organizer
      第130年会 日本薬学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 微量金属の神経毒性と神経変性疾患2010

    • Author(s)
      川原正博
    • Organizer
      第130年会 日本薬学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] プリオン蛋白による培養細胞に対する亜鉛および銅の影響2010

    • Author(s)
      小山裕也,永田哲也,定金豊,大塚功,戸泉文江,横山祥子,川原正博
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2011 Final Research Report
  • [Presentation] carnosine誘導体合成とGT1-7系における神経細胞保護効果2010

    • Author(s)
      鳥や尾篤、宮越辰則、反田和宏,渡邉暁子、坂本正徳、木葉敬子、定金豊、川原正博、山崎哲郎
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      岡山
    • Related Report
      2011 Final Research Report
  • [Presentation] プリオンペプチド断片(106-126)中のアスパラギン残基の自発的構造変化と生理機能2010

    • Author(s)
      定金豊,小山裕也、大塚功、川原正博
    • Organizer
      第27回日本薬学会九州支部大会
    • Place of Presentation
      長崎
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] PrP断片ペプチドの神経毒性に対する亜鉛および銅の影響2010

    • Author(s)
      小山裕也、永田哲也、定金豊、川原正博
    • Organizer
      第27回日本薬学会九州支部大会
    • Place of Presentation
      長崎
    • Related Report
      2011 Final Research Report
  • [Presentation] Alterations of gene expressions during neuronal death after zinc exposure : implications of calcium dyshomeostasis2010

    • Author(s)
      Kawahara M., Koyama H., Sadakane Y.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] プリオン蛋白断片ペプチドのコンフォメーション変化と神経毒性に及ぼす微量金属の影響2010

    • Author(s)
      川原正博、小山裕也、定金豊
    • Organizer
      第2回メタロミクス研究フォーラム
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Effects of zinc and copper on conformational changes and neurotoxicity of prion fragment peptide(PrP106-126)2010

    • Author(s)
      小山裕也、定金豊、大塚功、川原正博
    • Organizer
      第20回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      徳島
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of zinc and copper on conformational changes and neurotoxicity of prion fragment peptide (PrP106-126)2010

    • Author(s)
      小山裕也、定金豊、大塚功、川原正博
    • Organizer
      第20回金属の関与する生体関連反応シンポジウム(SRM2010)
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖鎖結合タンパク質に適した光化学的スクリーニング法の開発2009

    • Author(s)
      定金豊,木葉敬子,川原正博,畑中保丸
    • Organizer
      第26回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-12-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 糖鎖結合タンパク質に適した光化学的スクリーニング法の開発2009

    • Author(s)
      定金豊
    • Organizer
      第26回 日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経疾患に関わるペプチド中のアスパラギンおよびアスパラギン酸残基の構造的変化と生理活性2009

    • Author(s)
      定金豊
    • Organizer
      京都大学原子炉実験所・専門研究会「第2回タンパク質の異常凝集とその防御・修復機構に関する研究会」
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 宮崎県産海産物から老年性認知症予防・治療薬を探索する2009

    • Author(s)
      川原正博
    • Organizer
      第3回薬学研究フォーラムin東京-九州からの情報発信-
    • Place of Presentation
      東京
    • Year and Date
      2009-11-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 老年性認知症治療薬の開発に向けて2009

    • Author(s)
      川原正博
    • Organizer
      都市エリア産学官連携事業 浜辺のセミナー
    • Place of Presentation
      宮崎
    • Year and Date
      2009-09-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of Alternation of A-Asp and L-Asn residures in peptides related to conformational disease2009

    • Author(s)
      Sadakane Y, Konoha K, Kawahara M, Nakagomi K
    • Organizer
      International D-amino acid Research
    • Place of Presentation
      Awazi Inland, Japan
    • Year and Date
      2009-07-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of Alternation of A-Asp and L-Asn residures in peptides related to conformational disease2009

    • Author(s)
      Sadakane Y, Konoha K, Kawahara M, Nakagomi K
    • Organizer
      International D-amino acid Research (IDAR2009)
    • Place of Presentation
      Awaji Irland, Japan
    • Year and Date
      2009-07-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Carnosine inhibits s-sheet formation of PrP106-126 and protects against its neurotoxicity2009

    • Author(s)
      Kawahara M, T. Nagata, K. Konoha, Y. Sadakane
    • Organizer
      International Conference on Alzheimer's disease and related disorders
    • Place of Presentation
      Wien
    • Related Report
      2011 Final Research Report
  • [Presentation] Carnosine inhibits β-sheet formation of PrP106-126 and protects against its neurot oxicitv2009

    • Author(s)
      Kawahara M, Nagata T, Konoha K, Sadakane Y
    • Organizer
      International Conference of Alzheimer's Disease (ICAD2009)
    • Place of Presentation
      Wien, Austria
    • Related Report
      2009 Annual Research Report
  • [Book] Disruption of calcium homeostasis in Alzheimer's disease : role of channel formation byβAmyloid Protein, In "Neurodegenerative Diseases/Book 2"2011

    • Author(s)
      Kawahara M., Koyama H., Ohkawara S., Kato-Negishi M.
    • Related Report
      2011 Final Research Report
  • [Book] Disruption of calcium homeostasis in Alzheimer's disease : role of channel formation by β Amyloid Protein In "Neurodegenerative Diseases/Book 2", ISBN 979-953-307-672-9(Ed by Ivana Zach)2011

    • Author(s)
      Kawahara M., Koyama H., Ohkawara S., Kato-Negishi M
    • Publisher
      InTech
    • Related Report
      2011 Annual Research Report
  • [Book] Protective substances against zinc-induced neuronal death after ischemia : carnosine as a target for drug of vascular type of dementia. In Frontiers in CNS Drug Discovery2010

    • Author(s)
      Kawahara M, Konoha K, Tetsuya N and Sadakane Y
    • Publisher
      Bentham Science Publishers
    • Related Report
      2011 Final Research Report
  • [Book] Quantification of structural alterations of L-Asp and L-Asn residues in peptides related to neuronal disease by reversed-phase HPLC. In D-Amino Acids in chemistry, Life Sciences and Biotechnology2010

    • Author(s)
      Sadakane Y., Konoha K., Kawahara M., Nakagomi K. Hans Bruckner and Noriko Fujii
    • Related Report
      2011 Final Research Report
  • [Book] Aluminum and human health : possible link with neurodegenerative disorders. In Metals and Neurodegeneration2010

    • Author(s)
      Kawahara M
    • Related Report
      2011 Final Research Report
  • [Book] Metals and Neurodegeneration (Editor : Shile Huang)2010

    • Author(s)
      Kawahara M:
    • Publisher
      Aluminum and human health : possible link with neurodegenerative disorders. (Research Signpost)
    • Related Report
      2010 Annual Research Report
  • [Book] 認知症予防候補物質の探索と単離・構造決定、「薬学分析科学の最前線」、日本薬学会物理系薬学部会・分析化学担当教員会議編2009

    • Author(s)
      川原正博、定金豊
    • Publisher
      じほう
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 脳血管性認知症の治療剤および該治療剤を含有する飲食物、補助食品2009

    • Inventor(s)
      川原正博、定金豊、木葉敬子
    • Industrial Property Rights Holder
      九州保健福祉大学
    • Patent Publication Number
      2009-249335
    • Filing Date
      2009-10-29
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2017-10-13  

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