Molecular mechanism of zinc-induced neurotoxicity : involvement of Ca and ER stress
Project/Area Number |
21590145
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Environmental pharmacy
|
Research Institution | Kyushu University of Health and Welfare |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
SADAKANE Yutaka 鈴鹿医療科学大学, 薬学部, 教授 (60293304)
KOYAMA Hironari 九州保健福祉大学, 薬学部, 助手 (70567718)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 中毒学 / 無機金属毒性 / 亜鉛 / カルシウム / アポトーシス / カルノシン / プリオン / コンフォメーション / 銅 / 小胞体ストレス / アルツハイマー病 / プリオン病 / 脳血管性認知症 / イメージング |
Research Abstract |
Zinc(Zn) is neurotoxic and causes neurodegeneration following transient global ischemia and plays a crucial role in the pathogenesis of vascular-type dementia. We investigated the molecular mechanisms of Zn-induced neurotoxicity in vitro. The analysis of upregulated genes during Zn-induced neuronal death revealed that the significance of ER stress. These new results indicate that the disruption of Ca2+homeostasis and ER stress in the molecular mechanism of Zn-induced neurotoxicity, and are useful for the search for protective substances for vasucular dementia.
|
Report
(4 results)
Research Products
(74 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article]2010
Author(s)
Kawahara M
-
Journal Title
Metals and Neurodegeneration (Editor : Shile Huang)(Research Signpost)
Pages: 15-56
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-