Study on health risk assessment of chlorinated polycyclic aromatic hydrocarbons
Project/Area Number |
21590147
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Environmental pharmacy
|
Research Institution | National Institute of Health Sciences |
Principal Investigator |
NISHIMURA Tetsuji 国立医薬品食品衛生研究所, 生活衛生化学部, 部長 (20156110)
|
Co-Investigator(Renkei-kenkyūsha) |
SUGIMOTO Naoki (50300918)
SHIMIZU Kumiko
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 多環芳香族炭化水素 / B[a] P / 塩素置換体 / 遺伝毒性 / Ah受容体 / 発生期 / 多環芳香族炭化水素類 / B[a]P / 変異原性 / 染色体異常 / in vitro試験 / 暴露 / リスク評価 / 細胞毒性 / 分化 / qNMR |
Research Abstract |
The standards of chlorinated and bromated benzo[a] pyrenes were produced by chemical modification. After purification, the purities of these compounds were 94.6% of mono-chlorinated B[a] P replaced on 6 position, 97.2% of mono-bromated B[a] P replaced on 6 position, 94.6% of di-chlorinated B[a] P mixtures replaced 6, 11-and 6, 13-positions. These halogenated B[a] Ps showed weak toxicities on the cells and mutagenecities under the condition of metabolic activation. However, there were results of indicating the possibility of adverse effects on the nerve development process. The abundance was very little.
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Report
(4 results)
Research Products
(10 results)
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[Presentation] Generation and toxicities of halogenated benzo[a] pyrene2011
Author(s)
Nishimura, T., Shimizu, K., Kubota, R., Kobayashi, N., Tahara, M., Obama, T., Hirose, A., Sugimoto, N.
Organizer
The 31st International Symposium on Halogenated Persistent Organic Pollutants
Place of Presentation
Brussels, Belgium
Year and Date
2011-08-23
Related Report
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