Kinetics of Dysglycemia Induced by New Quinolone Antibiotics

• Project/Area Number: 21590151
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: YASUHARA Masato 東京医科歯科大学, 医学部・附属病院, 教授 (00127151)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: ニューキノロン系抗菌薬 / ガチフロキサシン / シベンゾリン / 血糖値異常 / ファーマコキネティックス / ファーマコダイナミックス / ペンタミジン / ファーマコキネティクス / 間接モデル / ファーマコキネテックス / 間モデル / インスリン

Research Abstract

Gatifloxacin, a fluoroquinolone antibacterial agent, caused hypoglycemia in rats after i. v. administration by increasing the serum concentration of insulin. At higher serum concentration of gatifloxacin, it promoted histamine release, leading to an increased serum epinephrine concentration and hyperglycemia. Cibenzoline induced a rapid increase in the serum concentration of insulin. As the cibenzoline dose was increased, a greater hypoglycemic effect occurred. The time courses of serum concentrations of cibenzoline, insulin and glucose could be described by the pharmacokinetic and pharmacodynamic model developed.

Research Products

• [Journal Article] Pharmacodynamics of cibenzoline-induced hypoglycemia in rats (2011)
  • Author(s): Y. Takahashi, Y. Ishiwata, Y. Kojima, M. Yasuhara
  • Journal Title: Drug Metab. Pharmacokin. Volume: 36 Pages: 242-247
  • NAID: 130004463184
  • Peer Reviewed
• [Journal Article] Pharmacodynamics of Cibenzoline-Induced Hypoglycemia in Rats (2011)
  • Author(s): Y.Takahashi
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 26 Issue: 3 Pages: 242-247
  • DOI: 10.2133/dmpk.DMPK-10-RG-127
  • NAID: 130004463184
  • ISSN: 1347-4367, 1880-0920
  • Peer Reviewed
• [Journal Article] Gatifloxacin-induced histamine release and hyperglycemia in rats (2010)
  • Author(s): Y. Ishiwata, M. Yasuhara
  • Journal Title: Eur. J. Pharmacol. Volume: 645 Pages: 192-197
  • Peer Reviewed
• [Journal Article] Deficiency of chemokine receptor CCR1 causes osteopenia due to impaired functions of osteoclasts and osteoblasts (2010)
  • Author(s): A. Hoshino, T. Iimura, S. Ueha, S. Hanada, Y. Maruoka, M. Mayahara, K. Suzuki, T. Imai, M. Ito, Y. Manome, M. Yasuhara, T. Kirino, A. Yamaguchi, K. Matsuhima, K. Yamamoto
  • Journal Title: J. Biol. Chem. Volume: 285 Pages: 28826-28837
  • Peer Reviewed
• [Journal Article] Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement (2010)
  • Author(s): Y. Nakauchi, H. Takase, S. Sugita, M. Mochizuki, S. Shibata, Y. Ishiwata, Y. Shibuya, M. Yasuhara, O. Miura, A. Arai
  • Journal Title: Int. J. Hematol. Volume: 92 Pages: 179-185
  • NAID: 10026512401
  • Peer Reviewed
• [Journal Article] Pharmacokinetic monitoring is still required for intravenous busulfan in SCT for small children (2010)
  • Author(s): M. Nagasawa, N. Mitsuiki, T. Ono, M. Takagi, H. Oda, M. Yasuhara, S. Mizutani
  • Journal Title: Int. J. Hematol. Volume: 91 Pages: 728-730
  • NAID: 10026402408
  • Peer Reviewed
• [Journal Article] Gatifloxacin-induced histamine release and hyperglycemia inrats. (2010)
  • Author(s): Y.Ishiwata
  • Journal Title: Eur.J.Pharmacol. Volume: 645 Pages: 192-197
  • Peer Reviewed
• [Journal Article] Deficiency of chemokine receptor CCR1 causes osteopenia dueto impaired functions of osteoclasts and osteoblasts. (2010)
  • Author(s): A.Hoshino
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 28826-28837
  • Peer Reviewed
• [Presentation] Effect of Pentamidine on Serum Glucose Concentration in Rats (2011)
  • Author(s): Seiji Karakawa
  • Organizer: 第5回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 名古屋大学医学部附属病院
  • Year and Date: 2011-11-26
• [Presentation] クロルフェニラミンの痙攣に及ぼすレボフロキサシン及びカフェインの影響 (2011)
  • Author(s): 小坂貴子, 他
  • Organizer: 日本薬剤学会第26年会
  • Place of Presentation: 東京
• [Presentation] Effect of pentamidine on serum glucose concentration in rats (2011)
  • Author(s): S. Karakawa, et al.
  • Organizer: 第5回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 名古屋
• [Presentation] ラットにおけるシベンゾリンの低血糖に関するファーマコダイナミックス (2010)
  • Author(s): 高橋裕, 他
  • Organizer: 医療薬学フォーラム
  • Place of Presentation: 広島
• [Presentation] Pharma-codynamics of gatifloxacininduced dysglycemia in rats (2010)
  • Author(s): M. Yasuhara, Y. Ishiwata
  • Organizer: 12th Buffalo Pharmaceutics Symposium
  • Place of Presentation: Buffalo, New York
• [Presentation] Effects of experimental renal failure on the pharmacokinetics of cibenzoline in rats (2009)
  • Author(s): Y. Ishiwata, et al.
  • Organizer: 日本薬物動態学会第24年会
  • Place of Presentation: 京都
• [Presentation] Effects of experimental renal failure on the pharmacokinetics of cibenzoline in rats (2009)
  • Author(s): Masato Yasuhara
  • Organizer: 日本薬物動態学会第24年会
  • Place of Presentation: 国立京都国際会館
• [Remarks]
  • URL: http://www.tmd.ac.jp/medhospital/medicine/framepage1.html